FlyBase Allele Report: Dmel\hep[r39]

General Information

Symbol

Dmel\hep^r39

Species

D. melanogaster

Name

FlyBase ID

FBal0045849

Feature type

allele

Associated gene

Dmel\hep

Associated Insertion(s)

Carried in Construct

Key Links

Allele class

amorphic allele - genetic evidence

Mutagen

PM hybrid dysgenesis

Nature of the Allele

Allele class

amorphic allele - genetic evidence

(Glise et al., 1995)

Mutagen

PM hybrid dysgenesis

(Glise et al., 1995)

Progenitor genotype

hep¹

(Glise et al., 1995)

Cytology

Description

Excision of the P-element insertion.

(Glise et al., 1995)

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal neuroanatomy | somatic clone

(Rallis et al., 2010)

lethal | recessive

(Agnes et al., 1999, Holland et al., 1997)

visible (with hep¹)

(Agnes et al., 1999)

Phenotype Manifest In

adult thorax (with hep¹)

(Agnes et al., 1999)

axon | somatic clone

(Rallis et al., 2010)

chaeta (with hep¹)

(Agnes et al., 1999)

imaginal disc

(Agnes et al., 1999)

Kenyon cell | somatic clone

(Rallis et al., 2010)

wing disc

(Agnes et al., 1999)

Detailed Description

Statement

Reference

hep^r39 neuroblast clones in mushroom bodies show axonal degeneration, though the main observable phenotype is overextension of axons.

(Rallis et al., 2010)

Discs dissected from L3 larvae are delayed in their development, reduced in size, and malformed or misfolded. Dissected pupae reveal one consistent and major defect: the absence or aberrant spreading and fusion of the two lateral wing discs. In some cases eversion does take place, in the absence of disc fusion. In viable hep^r39/hep^r75 transheterozygotes wing disc morphogenesis can proceed almost normally, with occasional unilateral defects. hep^r39/hep¹ adult females show mutant cleft thorax and bristle defects.

(Agnes et al., 1999)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Suppressed by

Statement

Reference

hep^r39/hep¹ has visible phenotype, suppressible by puc^E69

(Agnes et al., 1999)

NOT suppressed by

Statement

Reference

hep^r39 has abnormal neuroanatomy | somatic clone phenotype, non-suppressible by Scer\GAL4^ey-OK107/Mkk4^UAS.YFP

(Rallis et al., 2010)

hep^r39 has lethal phenotype, non-suppressible by Mmus\Map2k7^Ubi-p63E.PH

(Holland et al., 1997)

hep^r39 has lethal phenotype, non-suppressible by Xlae\Mek2^Ubi-p63E.PH

(Holland et al., 1997)

hep^r39 has lethal phenotype, non-suppressible by Mmmm\Sek1^Ubi-p63E.PH

(Holland et al., 1997)

Other

Statement

Reference

Mkk4^e01485, hep^r39 has abnormal neuroanatomy | somatic clone | adult stage phenotype

(Rallis et al., 2013)

Phenotype Manifest In

Suppressed by

Statement

Reference

hep^r39 has wing disc phenotype, suppressible by puc^E69

(Agnes et al., 1999)

hep^r39/hep¹ has adult thorax phenotype, suppressible by puc^E69

(Agnes et al., 1999)

hep^r39/hep¹ has chaeta phenotype, suppressible by puc^E69

(Agnes et al., 1999)

hep^r39 has imaginal disc phenotype, suppressible by puc^E69

(Agnes et al., 1999)

NOT suppressed by

Statement

Reference

hep^r39 has Kenyon cell | somatic clone phenotype, non-suppressible by Scer\GAL4^ey-OK107/Mkk4^UAS.YFP

(Rallis et al., 2010)

hep^r39 has axon | somatic clone phenotype, non-suppressible by Scer\GAL4^ey-OK107/Mkk4^UAS.YFP

(Rallis et al., 2010)

Other

Statement

Reference

Mkk4^e01485, hep^r39 has alpha/beta Kenyon cell | somatic clone phenotype

(Rallis et al., 2013)

Additional Comments

Genetic Interactions

Statement

Reference

28 day old flies containing hep^r39 Mkk4^e01485 double mutant neuroblast clones exhibit β-axon loss in the mushroom body.

(Rallis et al., 2013)

The axon degeneration and overextension phenotypes of hep^r39 neuroblast clones in mushroom bodies is not suppressed by expression of Mkk4^{Scer\UAS.T:Avic\GFP-YFP} using Scer\GAL4^ey-OK107.

(Rallis et al., 2010)

Double mutants with puc^E69/+ show discs of uniform size intermediate between those of wild type and unsuppressed hep single mutants. In combination with puc^E69 the hep^r39/hep¹ adult defects are strongly reduced.

(Agnes et al., 1999)

Xenogenetic Interactions

Statement

Reference

The lethality of hemizygous males is not significantly rescued by Mmus\Prkmk7^Ubi-p63E.PH, Xlae\Mek2^Ubi-p63E.PH or Mmmm\Sek1^Ubi-p63E.PH.

(Holland et al., 1997)

Complementation and Rescue Data

Rescued by

hep^r39 is rescued by hep^UAS.cBa/Scer\GAL4^ey-OK107

(Rallis et al., 2010)

Comments

Expression of hep^Scer\UAS.cBa with Scer\GAL4^ey-OK107 rescues the axonal phenotypes seen in hep^r39 mushroom body clones.

(Rallis et al., 2010)

The lethality of hemizygous males is rescued by hep^Ubi-p63E.PG, giving rise to viable, fertile adults in 48% of cases.

(Holland et al., 1997)

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (2)

Reported As

Symbol Synonym

hep^R39

(Rallis et al., 2013, Rallis et al., 2010)

hep^r39

Name Synonyms

Secondary FlyBase IDs

References (5)

Report Sections

Open Close