Amino acid replacement: E695K. Conserved residue in the JH2 (kinase-like) domain.
Amino acid replacement: E695K. Substitution in the kinase-like domain.
G11364091A
E695K | hop-PA
E695K
Site of nucleotide substitution in mutant inferred by FlyBase based on reported amino acid change.
Melanotic tumour formation varies among individuals and melanotic tumours can result from haematopoietic abnormalities and from the melanisation of gastric caecae and gut tissue. In the haematopoietic system an overproliferation of phagocytic plasmatocytes is observed.
Overproliferation and premature differentiation of haemocytes.
hopT42 has melanotic mass phenotype phenotype, suppressible by Stat92EF/Stat92E[+]
hopT42 has melanotic mass phenotype phenotype, suppressible by Galphaf[+]/Gαfc05874
hopT42 has melanotic mass phenotype phenotype, suppressible by Gαf4B7/Gαf[+]
hopT42 has melanotic mass phenotype phenotype, suppressible by Rho11B/Rho1[+]
hopT42 has melanotic mass phenotype phenotype, suppressible by Stat92E397/Stat92E[+]
hopT42 has melanotic mass phenotype | dominant | heat sensitive phenotype, suppressible by Stat92E06346
hopT42 has increased mortality phenotype, suppressible by Stat92E06346
hopT42 has increased occurrence of cell division phenotype, non-suppressible by Stat92E06346
hopT42 has increased occurrence of cell division phenotype, non-suppressible by Stat92EHJ
hopT42 has melanotic mass phenotype, suppressible by Stat92E397/Stat92E[+]
hopT42 has melanotic mass phenotype, suppressible by Stat92EF/Stat92E[+]
hopT42 has melanotic mass phenotype, suppressible by Galphaf[+]/Gαfc05874
hopT42 has melanotic mass phenotype, suppressible by Gαf4B7/Gαf[+]
hopT42 has melanotic mass phenotype, suppressible by Rho11B/Rho1[+]
hopT42 has phenotype, suppressible by Stat92E06346
Phenotype is partially suppressed by a reduction of wild type Stat92E activity, Stat92E06346. Female mortality and male and female tumour formation are reduced, male lethality is not rescued. Stat92E06346 and Stat92EHJ can suppress the premature differentiation and aggregation but not the overproliferation of larval haemocytes.