FlyBase Allele Report: Dmel\mei-41[RT2]

General Information

Symbol

Dmel\mei-41^RT2

Species

D. melanogaster

Name

FlyBase ID

FBal0046108

Feature type

allele

Associated gene

Dmel\mei-41

Associated Insertion(s)

P{}mei-41^RT2

Carried in Construct

Key Links

Allele class

Mutagen

Nature of the Allele

Allele class

Mutagen

PM hybrid dysgenesis

(Yamamoto et al., 1990)

P-element activity

(Banga et al., 1995, Hari et al., 1995, Banga et al., 1991)

Progenitor genotype

Associated Insertion(s)

P{}mei-41^RT2

Cytology

Description

Insertion of P-element into the same SalI-EcoRI genomic fragment that includes the insertion in mei-41^RT1, though in opposite orientation to P-element in mei-41^RT1.

(Banga et al., 1995)

Insertion of a P-element.

(Banga et al., 1991)

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal DNA repair

(Brodsky et al., 2000)

chemical sensitive

(Yamamoto et al., 1990)

chemical sensitive | recessive

(Banga et al., 1995)

female semi-sterile

(Laurencon et al., 2003)

female sterile | heat sensitive

(Yamamoto et al., 1990)

female sterile | recessive

(Banga et al., 1995)

viable

(Laurencon et al., 2003)

Phenotype Manifest In

Detailed Description

Statement

Reference

The number of mitotic cells in the mei-41^RT2 eye disc is unchanged following irradiation, in contrast to wild-type discs where very few cells are in M phase after irradiation. The morphology of the eye disc and adult eye is normal in unirradiated mei-41^RT2 animals.

(Brodsky et al., 2000)

Homozygotes are sensitive to MMS and show female sterility.

(Banga et al., 1995)

Methyl methanesulfonate sensitive, exposure causes lethality. Frequency of XO males and XXY females suggests high rates of chromosome loss.

(Yamamoto et al., 1990)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Phenotype Manifest In

Enhancer of

Statement

Reference

mei-41^RT2 is an enhancer of eye phenotype of RecQ5^UAS.cNa, Scer\GAL4^GMR.PF

(Nakayama et al., 2006)

mei-41^RT2 is an enhancer of ommatidial precursor cluster phenotype of RecQ5^UAS.cNa, Scer\GAL4^GMR.PF

(Nakayama et al., 2006)

mei-41^RT2 is an enhancer of interommatidial bristle phenotype of RecQ5^UAS.cNa, Scer\GAL4^GMR.PF

(Nakayama et al., 2006)

Additional Comments

Genetic Interactions

Statement

Reference

The mei-41^RT2 mutant enhances the rough eye phenotype of RecQ5^Scer\UAS.cNa/Scer\GAL4^GMR.PF flies.

(Nakayama et al., 2006)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (1)

Kyoto

101153

mei-41^RT2 f¹ / In(1)FM7

Notes on Origin

Discoverer

Comments

mei-41^RT1 and mei-41^RT2 reside within 400bp of each other. Transposase induced reversion demonstrates a P-element insertion is responsible for the mutant phenotype.

(Yamamoto et al., 1990)

The chromosome carrying mei-41^RT2 is relatively stable in the absence of P\T^Δ2-3 (which encodes a functional transposase), however in the presence of P\T^Δ2-3 the stability of the mei-41^RT2 chromosome is reduced 50-fold.

(Banga et al., 1991)

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (1)

Reported As

Symbol Synonym

mei-41^RT2

(Nakayama et al., 2006, Brodsky et al., 2004)

Name Synonyms

Secondary FlyBase IDs

References (8)

Report Sections

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