FB2024_03 , released June 25, 2024
Allele: Dmel\sns15
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General Information
Symbol
Dmel\sns15
Species
D. melanogaster
Name
FlyBase ID
FBal0046372
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Key Links
Nature of the Allele
Progenitor genotype
Cytology
Description
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DNA sequence
Protein sequence
 
Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 0 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Disease-implicated variant(s)
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference

Homozygous embryos have defects in myoblast fusion.

Paired vesicles are present at wild type levels and disappear as in wild type. However, the plasma membrane never vesiculates, instead extensive electron-dense plaques are present along apposed plasma membranes between pairs of myoblasts during stage 13. By stage 14 electron dense plaques have disappeared, groups of myoblasts are aligned in the same positions as mature myotubes but the membranes have failed to fuse.

Dorsal vessel and visceral mesoderm is unaffected but major distortions occur in somatic mesoderm. Strong allele: Late stages of embryonic development show mostly unfused myoblasts. First distortions are visible during germ-band retraction. Unfused myoblasts are often arranged in specific locations where in the wild type ventral, pleural and longitudinal muscles form.

External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Phenotype Manifest In
Enhanced by
Statement
Reference

sns15 has embryonic myoblast phenotype, enhanceable by Vrp1D30

Additional Comments
Genetic Interactions
Statement
Reference

The myoblast fusion defects of sns15 Vrp1D30 double mutant embryos are more severe than those of sns15 single mutant embryos.

Xenogenetic Interactions
Statement
Reference
Complementation and Rescue Data
Comments
Images (0)
Mutant
Wild-type
Stocks (0)
Notes on Origin
Discoverer

Selected as: a mutation that shows lethality over the "rost30A" chromosome. The "rost30A" chromosome contains mutations in two genes: rost30A and sns43-49. sns15 has been shown to be allelic to sns43-49 rather than to rost30A.

External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (4)
Reported As
Name Synonyms
Secondary FlyBase IDs
    References (4)