FlyBase Allele Report: Dmel\scw[E2]

General Information

Symbol

Dmel\scw^E2

Species

D. melanogaster

Name

FlyBase ID

FBal0046426

Feature type

allele

Associated gene

Dmel\scw

Associated Insertion(s)

Carried in Construct

Key Links

Allele class

antimorphic allele - genetic evidence

Mutagen

ethyl methanesulfonate

Nature of the Allele

Allele class

antimorphic allele - genetic evidence

(Raftery et al., 1995)

Mutagen

ethyl methanesulfonate

(Raftery et al., 1995)

Progenitor genotype

Cytology

Description

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

lethal - all die during embryonic stage | recessive

(Raftery et al., 1995)

some die during embryonic stage | recessive

(Raftery et al., 1995)

Phenotype Manifest In

embryonic/larval posterior spiracle

(Raftery et al., 1995)

Detailed Description

Statement

Reference

Heterozygotes with Df(2L)OD16 exhibit partial head involution and limited loss of dorsal tissue. Embryo also have a 'tail-up' phenotype and the posterior spiracles are disorganised.

(Raftery et al., 1995)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Suppressed by

Statement

Reference

scw^E2 has lethal phenotype, suppressible by Dp(2;2)DTD48

(Raftery et al., 1995)

Other

Statement

Reference

sax¹, scw^E2/scw[+] has lethal | dominant | maternal effect phenotype

(Twombly et al., 2009)

sax², scw^E2/scw[+] has lethal | dominant | maternal effect phenotype

(Twombly et al., 2009)

sax^P, scw^E2/scw[+] has lethal | dominant | maternal effect phenotype

(Twombly et al., 2009)

Phenotype Manifest In

Enhancer of

Statement

Reference

scw^E2 is an enhancer of phenotype of dpp^hr4

(Raftery et al., 1995)

Additional Comments

Genetic Interactions

Statement

Reference

sax¹ heterozygous mothers generate synthetic lethality when crossed to scw^E2/+ males.

sax² heterozygous mothers generate synthetic lethality when crossed to scw^E2/+ males.

sax^P heterozygous mothers generate synthetic lethality when crossed to scw^E2/+ males.

(Twombly et al., 2009)

Lethal when in trans to scw^- mutation. This lethality can be partially rescued by one extra copy of dpp⁺ (Dp(2;2)DTD48, dpp^d-ho). Zygotic lethal interaction with dpp^hr4 is due to a loss of dorsal-most fates in the embryos, demonstrated by loss of amnioserosa cells.

(Raftery et al., 1995)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (1)

Bloomington

78331

dpy^ov1 scw^E2 cn¹ bw¹/CyO, P{dpp-P23}RP1

Notes on Origin

Discoverer

Comments

Mutation is either antimorphic against dpp (if dpp and scw normally act in the same pathway) or neomorphic (if dpp and scw normally act in parallel pathways). Similar dorsal-ventral patterning defects suggest the genes act in the same pathway.

(Raftery et al., 1995)

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (1)

Reported As

Symbol Synonym

scw^E2

(Twombly et al., 2009)

Name Synonyms

Secondary FlyBase IDs

References (3)

Report Sections

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