FB2024_03 , released June 25, 2024
Allele: Dmel\tldE1
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General Information
Symbol
Dmel\tldE1
Species
D. melanogaster
Name
FlyBase ID
FBal0046586
Feature type
allele
Associated gene
Dmel\tld
Associated Insertion(s)
Carried in Construct
Key Links
Genomic Maps

Allele class
Mutagen
Nature of the Allele
Allele class
Mutagen
ethyl methanesulfonate
(Raftery et al., 1995)
Progenitor genotype
Cytology
Description

Amino acid replacement: Y272N. Amino acid replacement: I51M.

(Raftery et al., 1995)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
point_mutation
3R:24,749,978..24,749,978 [+]
Nucleotide change:

T24749978G

Amino acid change:

I61M | tld-PA

Reported amino acid change:

I51M

Comment:

Position of mutation on reference sequence inferred by FlyBase curator. Difference beteween actual and reported amino acid substitution due to authors using M11 as the start Met. One of two mutations in this strain.

(Raftery et al., 1995)
point_mutation
3R:24,750,900..24,750,900 [+]
Nucleotide change:

T24750900A

Amino acid change:

Y282N | tld-PA

Reported amino acid change:

Y272N

Comment:

Position of mutation on reference sequence inferred by FlyBase curator. Difference beteween actual and reported amino acid substitution due to authors using M11 as the start Met. One of two mutations in this strain.

(Raftery et al., 1995)
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Embryonic lethal when transheterozygous with tld- mutations.

      (Raftery et al., 1995)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Enhancer of
      Statement
      Reference

      tldE1 is an enhancer of phenotype of dpphr4

      (Raftery et al., 1995)
      Other
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      Lethal interaction with dpphr4 is due to a loss of dorsal-most fates in the embryos, demonstrated by loss of amnioserosa cells. dpphr4/dpp+;tldE1/tld+ embryos completely fail to involute the head structures and is missing portions of the head skeleton. Posterior most structures including the filzkorper are internal, presumably due to the failure of germband retraction.

      (Raftery et al., 1995)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (1)
      Reported As
      Symbol Synonym
      tldE1
      Name Synonyms
      Secondary FlyBase IDs
        References (1)