FB2024_03 , released June 25, 2024
Allele: Dmel\RopF3
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General Information
Symbol
Dmel\RopF3
Species
D. melanogaster
Name
FlyBase ID
FBal0048937
Feature type
allele
Associated gene
Dmel\Rop
Associated Insertion(s)
Carried in Construct
Key Links
Genomic Maps

Allele class
Mutagen
Nature of the Allele
Allele class
Mutagen
ethyl methanesulfonate
(Harrison et al., 1994)
Progenitor genotype
Cytology
Description

Amino acid replacement: R50C.

(Harrison et al., 1994)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
point_mutation
3L:4,138,667..4,138,667 [-]
Nucleotide change:

C4138667T

Amino acid change:

R50C | Rop-PA; R50C | Rop-PB

Reported amino acid change:

R50C

Comment:

Site of nucleotide substitution in mutant inferred by FlyBase based on reported amino acid change.

(Harrison et al., 1994)
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Homozygous larvae show a significant increase in the amplitude of the excitatory junctional potential in the muscle at the neuromuscular junction compared to control larvae. Synaptic morphology appears normal. RopG17/RopF3 larvae have a similar phenotype.

      (Wu et al., 1998)

      ERGs of heterozygotes demonstrate a reversible block in synaptic transmission, the viability of photoreceptor cells and lamina cells is not affected as they recover at the permissive temperature.

      (Harrison et al., 1994)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Fails to complement

      RopG27

      (Wu et al., 1998)

      RopA19

      (Wu et al., 1998)
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      RopF3
      ropF3
      (Wu et al., 1998)
      Name Synonyms
      Secondary FlyBase IDs
        References (5)