FB2024_03 , released June 25, 2024
Allele: Dmel\ttkB330
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General Information
Symbol
Dmel\ttkB330
Species
D. melanogaster
Name
FlyBase ID
FBal0050675
Feature type
allele
Associated gene
Dmel\ttk
Associated Insertion(s)
Carried in Construct
Key Links
Allele class

hypomorphic allele - genetic evidence

loss of function allele

Mutagen
Nature of the Allele
Allele class

hypomorphic allele - genetic evidence

(Giesen et al., 1997)

loss of function allele

(Salzberg et al., 1994)
Mutagen
ethyl methanesulfonate
(Giesen et al., 1997, Salzberg et al., 1994)
Progenitor genotype
Cytology
Description
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In

      midline glial cell

      (Giesen et al., 1997)

      thecogen cell & peripheral nervous system

      (Salzberg et al., 1994)
      Detailed Description
      Statement
      Reference

      Lateral glial cells are present but they fail to organise into the regular pattern seen in wild type embryos. In the CNS of stage 16 embryos the number of lateral glial cells is reduced by about 20%. Midline glial cells are still specified but fail to properly differentiate and instead of migrating between the two segmental commissures that remain anterior to the commissures which subsequently appear fused. In stage 16 embryos the midline glial cells start to degenerate and are cleared from the nervous system. pnt ttk double mutant flies display an additive CNS phenotype combining characteristics of both phenotypic traits.

      (Giesen et al., 1997)

      Defect in embryonic PNS development: gain of neurons, outer support cells are transformed into the lineage-related neuron and glia.

      (Salzberg et al., 1994)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      ttkB330 has minor effects on the neuronal defects seen in embryos expressing gcmScer\UAS.cHa under the control of Scer\GAL4sca-T3.

      (Yuasa et al., 2003)

      The partial lethality due to runScer\UAS.cLa; Scer\GAL4nos.PG (3% viable) is partially suppressed by maternal heterozygosity for ttkB330 (rescues to 33% viable).

      (Wheeler et al., 2002)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Partially rescued by

      ttkB330 is partially rescued by ttkp69.UAS/Scer\GAL4sli.PS

      (Giesen et al., 1997)
      Comments

      Scer\GAL4sli.PS-mediated expression of ttkp69.Scer\UAS partially rescues the CNS phenotype.

      (Giesen et al., 1997)
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (1)
      Reported As
      Symbol Synonym
      ttkB330
      (Vander Zwan et al., 2003)
      Name Synonyms
      Secondary FlyBase IDs
        References (6)