FB2024_03 , released June 25, 2024
Allele: Dmel\mei-2186
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General Information
Symbol
Dmel\mei-2186
Species
D. melanogaster
Name
FlyBase ID
FBal0051348
Feature type
allele
Associated gene
Dmel\mei-218
Associated Insertion(s)
Carried in Construct
Key Links
Allele class
Mutagen
Nature of the Allele
Allele class
Mutagen
ethyl methanesulfonate
(McKim et al., 1996)
Progenitor genotype
Cytology
Description
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In

      meiosis & nuclear chromosome | female

      (Apionishev et al., 2001)
      Detailed Description
      Statement
      Reference

      Females show 30.5% X chromosome nondisjunction and 10.24% chromosome 4 nondisjunction.

      (Manheim et al., 2002)

      Homozygous females show 38% X chromosome nondisjunction and 18% 4th chromosome nondisjunction.

      (Apionishev et al., 2001)

      Reduces crossing over to a frequency similar to mei-2181, 3-7% of wild type. Reduction in crossing over is twofold less in the centromere proximal regions compared to the distal regions. High levels of nondisjunction on the X chromosome, lower levels on the 4th chromosome.

      (McKim et al., 1996)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Suppressed by
      Statement
      Reference

      mei-2186 has abnormal meiotic cell cycle | female phenotype, suppressible by lwr05486/lwr[+]

      (Apionishev et al., 2001)
      Phenotype Manifest In
      Suppressed by
      Statement
      Reference

      mei-2186 has meiosis & nuclear chromosome | female phenotype, suppressible by lwr05486/lwr[+]

      (Apionishev et al., 2001)
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      4th, but not X chromosome disjunction is suppressed in mei-2186 females if they also carry lwr05486/+.

      (Apionishev et al., 2001)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (1)
      Reported As
      Symbol Synonym
      mei-2186
      (Son and Chung, 2023, Hartmann et al., 2019, Kohl et al., 2012)
      Name Synonyms
      Secondary FlyBase IDs
        References (7)