FlyBase Allele Report: Dmel\mirr[B1-12]

General Information

Symbol

Dmel\mirr^B1-12

Species

D. melanogaster

Name

FlyBase ID

FBal0051410

Feature type

allele

Associated gene

Dmel\mirr

Associated Insertion(s)

P{lacW}mirr^B1-12

Carried in Construct

Also Known As

mirr-lacZ

Key Links

Allele class

Mutagen

P-element activity

Nature of the Allele

Allele class

Mutagen

P-element activity

(Choi et al., 1996)

Progenitor genotype

Associated Insertion(s)

P{lacW}mirr^B1-12

Cytology

Description

5' end of the cDNA is approximately 400bp apart from the P{lacW} insertion.

(Kehl et al., 1998)

Allele components

Component

Use(s)

Inserted element

P{lacW}

enhancer trap

Encoded product / tool

lacZ

reporter enzyme

Tagged with

Tag:NLS(P)

nuclear protein localization tag

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

lethal | recessive

(Choi et al., 1996)

lethal - all die during embryonic stage | recessive

(Zhao et al., 2000)

partially lethal - majority die

(Kehl et al., 1998)

some die during embryonic stage | recessive

(Zhao et al., 2000)

visible

(Kehl et al., 1998)

Phenotype Manifest In

alula

(Kehl et al., 1998)

anterior postalar bristle

(Kehl et al., 1998)

dorsal appendage (with mirr^P1)

(Zhao et al., 2000)

egg chorion (with mirr^P1)

(Zhao et al., 2000)

posterior supraalar bristle

(Kehl et al., 1998)

wing

(Kehl et al., 1998)

Detailed Description

Statement

Reference

mirr^B1-12/mirr^g14 females lay normal eggs, 100% of which hatch. mirr^P1/mirr^B1-12 females lay eggs with abnormal eggshells and small dorsal appendages (in 50% of cases), 100% of which hatch.

(Zhao et al., 2000)

Rare adult escapers. Homozygotes that escape lethality exhibit mild bristle defects, but have normal alula. Postalar bristle and alula are not affected heterozygotes. Transheterozygotes with mirr^Sai1 or mirr^Sai2 are semi-lethal. Rare adults exhibit outheld wings, the alulae are completely missing and postalar bristles are missing. Transheterozygotes with mirr^g14 or mirr^e48 survive to the adult stage ad also exhibit outheld wings, missing alulae and bristle defects. Transheterozygotes with Df(3L)iro-DFM1 are semi-lethal with rare escapers. Escapers show outheld wings, lack of alulae and deletion of the posterior supraalar bristle and/or anterior postalar bristle. Transheterozygotes with Tp(3;3)iro-1 are viable and show no obvious defects in the alula, but they do show deletion of presutural bristle and anterior postalar bristle.

(Kehl et al., 1998)

Adults escape lethality at rate of <1%.

(Choi et al., 1996)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Enhanced by

Statement

Reference

mirr^B1-12 has visible phenotype, enhanceable by Mob¹

(Kehl et al., 1998)

Other

Statement

Reference

Mob¹, mirr^B1-12/Tp(3;3)iro-1 has visible phenotype

(Kehl et al., 1998)

Phenotype Manifest In

Enhanced by

Statement

Reference

mirr^B1-12 has mesothoracic bristle phenotype, enhanceable by Mob¹

(Kehl et al., 1998)

Other

Statement

Reference

Mob¹, mirr^B1-12/Tp(3;3)iro-1 has mesothoracic bristle phenotype

(Kehl et al., 1998)

Additional Comments

Genetic Interactions

Statement

Reference

In combination with Mob¹ the alula are eliminated. In combination with Mob¹, mirr^B1-12/Tp(3;3)iro-1 transheterozygotes exhibit complete removal of the lateral macrobristles.

(Kehl et al., 1998)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (14)

Bloomington

78549