Nucleotide substitution: G376A. Amino acid replacement: R250H. In exon 5.
Point mutation in the homeodomain, Arg at the 53rd residue is changed to a His.
Amino acid replacement: R?H. R?H change maps to helix 3 of the homeodomain.
G6711593A
G376A
R250H | pb-PA; R245H | pb-PB; R245H | pb-PC; R240H | pb-PD
R250H
Flies carrying one or two copies of pbRev14.HSPB are wild type. Flies carrying pbRev14.HSPB are more active and agile than flies carrying the progenitor allele pbhs.PB.
Eliminates the antenna to maxillary palps transformation and the dose sensitive eye phenotype (re-establishment of normal hexagonal ommatidial form) of pbhs.PB.
pbRev14.HSPB fails to rescue pb4
Induced in P{HSPB} insert 2-5: identified through selection of flies with w+mC colored eyes but normal antennae. Increasing the copy number of this element in the genome has no effect on the phenotype caused by a single copy of pbhs.PB.