Construct: Amino acid replacement: G1015D. Amino acid replacement: T1017A. Amino acid replacement: K1018M. Amino acid replacement: F1020S.
Intracellular electrophysiological responses of photoreceptor cells in flies carrying ninaC1015.4 in a ninaC5 background are abnormal. There is a small defect in adaptation, as indicated by the slightly smaller light-coincident spike relative to wild type. There is a delay in termination and an ensuing slow deactivation.
Flies carrying ninaC717.3 in a ninaC5 background have a null electroretinogram phenotype and a retinal degeneration phenotype intermediate between wild-type and that of ninaC5 flies, at 25oC. The ERG is wild-type at 18oC. Retinal degeneration is severe at 29oC.
ninaC1015.4 partially rescues ninaC5