FlyBase Allele Report: Dmel\Cul3[GR18]

General Information

Symbol

Dmel\Cul3^GR18

Species

D. melanogaster

Name

FlyBase ID

FBal0061384

Feature type

allele

Associated gene

Dmel\Cul3

Associated Insertion(s)

Carried in Construct

Key Links

Genomic Maps

JBrowse

Allele class

Mutagen

gamma ray

Nature of the Allele

Allele class

Mutagen

gamma ray

(Mistry et al., 2004, Ashburner et al., 1999.10.12, Roote, 1997.6.6)

Progenitor genotype

Cytology

Description

Deletion of a single nucleotide at position 475, resulting in a frameshift at amino acid 158 and a premature stop at amino acid 167.

(Mistry et al., 2004)

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

deletion

2L:15,268,730..15,268,730 [-]

Comment:

Deletion of a single nucleotide, resulting in a frameshift at amino acid 158 and a premature stop at amino acid 167. Position of mutation on reference sequence inferred by FlyBase curator.

(Mistry et al., 2004)

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

male sterile (with Cul3^mds1)

(Arama et al., 2007, Arama et al., 2007)

male sterile (with Cul3^mds2)

(Arama et al., 2007)

male sterile (with Cul3^mds3)

(Arama et al., 2007)

male sterile (with Cul3^mds4)

(Arama et al., 2007)

male sterile (with Cul3^mds5)

(Arama et al., 2007)

Phenotype Manifest In

spermatid (with Cul3^mds1)

(Arama et al., 2007)

Detailed Description

Statement

Reference

cul-3^mds1/cul-3^GR18 spermatids show defects in individualisation.

(Arama et al., 2007)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Suppressor of

Statement

Reference

gft[+]/Cul3^GR18 is a suppressor of visible phenotype of Gαs^Q215L.UAS, Scer\GAL4^OK10

(Mistry et al., 2004)

Phenotype Manifest In

Additional Comments

Genetic Interactions

Statement

Reference

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Fails to complement

Cul3^mds5

(Arama et al., 2007)

Cul3^mds4

(Arama et al., 2007)

Cul3^mds3

(Arama et al., 2007)

Cul3^mds2

(Arama et al., 2007)

Cul3^mds1

(Arama et al., 2007)

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

Induced on: T(Y;2)TE35B-18.

(Mistry et al., 2004)

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (6)

Reported As

Symbol Synonym

Cul-3^GR18

Cul3^GR18

cul-3^GR18

cul3^gft<up>gr18</up>

(Arama et al., 2007)

cul3^gftGR18

(Arama et al., 2007)

gft^GR18

Name Synonyms

Secondary FlyBase IDs

References (5)

Report Sections

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