FlyBase Allele Report: Dmel\fz[unspecified]

General Information

Symbol

Dmel\fz^unspecified

Species

D. melanogaster

Name

FlyBase ID

FBal0061396

Feature type

allele

Associated gene

Dmel\fz

Associated Insertion(s)

Carried in Construct

Key Links

Allele class

Mutagen

Nature of the Allele

Allele class

Mutagen

Progenitor genotype

Cytology

Description

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal planar polarity

(Yan et al., 2008, Katanaev et al., 2005, Lawrence et al., 2004)

abnormal planar polarity | cell non-autonomous | somatic clone

(Lee and Adler, 2002, Gubb et al., 1999)

Phenotype Manifest In

leg joint | ectopic

(Gubb et al., 1999)

tarsal segment 1 & joint

(Gubb et al., 1999)

tarsal segment 2

(Gubb et al., 1999)

tarsal segment 3

(Gubb et al., 1999)

tarsal segment 4

(Gubb et al., 1999)

trichome & abdominal tergite

(Lawrence et al., 2004)

trichome & pleural membrane

(Lawrence et al., 2004)

wing | somatic clone

(Gubb et al., 1999)

wing hair

(Yan et al., 2008, Katanaev et al., 2005, Wong and Adler, 1993)

wing hair | cell non-autonomous | somatic clone

(Lee and Adler, 2002)

wing hair | increased number

(Katanaev et al., 2005)

wing hair | somatic clone

(Gubb et al., 1999)

wing margin bristle

(Katanaev et al., 2005)

Detailed Description

Statement

Reference

Wing hairs in the most anterior region of the wing point towards the anterior margin in mutants, as opposed to distally as in wild type.

(Yan et al., 2008)

Wing margin bristles point out of the wing in fz^unspecified mutants, in contrast to wild-type, where they point to the distal end of the wing. Defects in wing hair polarity are seen and a few multiple wing hairs appear.

(Katanaev et al., 2005)

The abdomen of fz^unspecified homozygous flies does not completely lack planar polarity. Dorsally, the only obvious abnormality is dishevelment in the anterior portion of the A compartment with occasional whorls elsewhere, particularly in the front of the P compartment. However, ventrally, the hairs of the pleura lack all anteroposterior bias; in some places they are randomly oriented, in others they point mostly laterally.

(Lawrence et al., 2004)

Mutant clones in the wing show domineering non-autonomy: cells distal to the clone, as well as within the clone, show alteration of polarity of wing hairs.

(Lee and Adler, 2002)

Extreme tarsal phenotypes are seen, with complete duplications in T2-T4 and an ectopic joint structure in T1. Somatic clones in the wing cause long-range non-autonomous alteration in the polarity of cells, both distal and lateral to the clone, which tend to point towards the mutant clone.

(Gubb et al., 1999)

Most wing cells of homozygous flies form a single hair. Homozygous flies have disruptions in the pattern of wing hair polarity. The prehair initiation site is moved to near the cell centre in pupal wing cells. Double mutants of fz^unspecified with in¹, fy² or mwh¹ resemble in¹, fy² or mwh¹ single mutants respectively.

(Wong and Adler, 1993)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

NOT Enhanced by

Statement

Reference

fz^unspecified has abnormal planar polarity phenotype, non-enhanceable by ft^unspecified

(Ma et al., 2003)

Suppressor of

Statement

Reference

fz^unspecified is a suppressor of abnormal planar polarity phenotype of Gαo^UAS.cKa, Scer\GAL4^Bx-MS1096

(Katanaev et al., 2005)

NOT Suppressor of

Statement

Reference

fz^unspecified is a non-suppressor of abnormal planar polarity phenotype of Gαo^GTP.UAS, Scer\GAL4^Bx-MS1096

(Katanaev et al., 2005)

Phenotype Manifest In

Enhanced by

Statement

Reference

fz^unspecified has phenotype, enhanceable by ds^33k/ds¹

(Adler et al., 1998)

fz^unspecified has phenotype, enhanceable by ds^33k

(Adler et al., 1998)

fz^unspecified has phenotype, enhanceable by ds^UAO71

(Adler et al., 1998)

Suppressor of

Statement

Reference

fz^unspecified/fz^unspecified is a suppressor of wing margin bristle phenotype of Gαo^UAS.cKa, Scer\GAL4^Bx-MS1096

(Katanaev and Tomlinson, 2006)

fz^unspecified is a suppressor of wing hair | increased number phenotype of Gαo^UAS.cKa, Scer\GAL4^Bx-MS1096

(Katanaev et al., 2005)

fz^unspecified is a suppressor of wing hair phenotype of Gαo^UAS.cKa, Scer\GAL4^Bx-MS1096

(Katanaev et al., 2005)

NOT Suppressor of

Statement

Reference

fz^unspecified is a non-suppressor of wing hair | increased number phenotype of Gαo^GTP.UAS, Scer\GAL4^Bx-MS1096

(Katanaev et al., 2005)

fz^unspecified is a non-suppressor of wing hair phenotype of Gαo^GTP.UAS, Scer\GAL4^Bx-MS1096

(Katanaev et al., 2005)

Other

Statement

Reference

fz2^unspecified, fz^unspecified has wing disc | somatic clone phenotype

(Johnston and Sanders, 2003)

Additional Comments

Genetic Interactions

Statement

Reference

Clones of stan^E59 fz^unspecified double mutant cells in the anterior compartment of the dorsal epidermis of the adult abdomen (in the tergite) do not change the cell polarity of their wild-type neighbouring cells.

The reversal of cell polarity that is seen in cells anterior to clones in the anterior compartment of the dorsal epidermis of the adult abdomen (in the tergite) where the clones are expressing ft^Scer\UAS.cMa under the control of Scer\GAL4^αTub84B.PL is still seen if the clones are induced in a fz^unspecified background.

Clones of ft^unspecified cells in the anterior compartment of the dorsal epidermis of the adult abdomen (in the tergite) that have been induced in a fz^unspecified background can reverse the cell polarity of cells behind the clone (hairs behind the clone point forwards).

The reversal of cell polarity that is seen in cells posterior to clones in the anterior compartment of the dorsal epidermis of the adult abdomen (in the tergite) where the clones are expressing ds^{ecto.Scer\UAS} under the control of Scer\GAL4^αTub84B.PL is still seen if the clones are induced in a fz^unspecified background.

The reversal of cell polarity phenotype seen in cells posterior to fz^unspecified clones in the anterior compartment of the dorsal epidermis of the adult abdomen (in the tergite) shows a longer range if the clones are induced in a ds^unspecified background compared to a wild-type background.

Clones of cells in the anterior compartment of the dorsal epidermis of the adult abdomen (in the tergite) where the clones are mutant for fz^unspecified and are also expressing ft^Scer\UAS.cMa under the control of Scer\GAL4^αTub84B.PL result in reversal of cell polarity in cells posterior to the clone when the clone is at the front of the anterior compartment (behaving like fz^- clones) and result in reversal of cell polarity in cells anterior to the clone when the clone is at the back of the anterior compartment (behaving like clones expressing ft^Scer\UAS.cMa under the control of Scer\GAL4^αTub84B.PL).

The reversal of cell polarity phenotype that is seen in cells posterior to clones in the anterior compartment of the dorsal epidermis of the adult abdomen (in the tergite) where the clones are doubly mutant for ptc¹⁶ and Df(2R)en^E is still seen if the clones are induced in a fz^unspecified background, as occurs in clones induced a wild-type background.

Clones of cells in the anterior compartment of the dorsal epidermis of the adult abdomen (in the tergite) where the clones are expressing fz^Scer\UAS.cUa under the control of Scer\GAL4^αTub84B.PL and the clones have been induced in a ds^unspecified fz^unspecified double mutant background, result in reversal of cell polarity for a single cell distance anterior to the clone.

(Casal et al., 2006)

The effects of overexpression of G-oα47A^Scer\UAS.cKa are suppressed in fz^unspecified homozygous wings. The effects of overexpression of G-oα47A^GTP.Scer\UAS are enhanced in fz^unspecified homozygous wings.

(Katanaev and Tomlinson, 2006)

The frequency of multiple wing hairs induced by expression of G-oα47A^Scer\UAS.cKa under the control of Scer\GAL4^Bx-MS1096 is reduced if the flies also carry fz^unspecified.

(Katanaev et al., 2005)

fz^unspecified fz2^unspecified double mutant clones induced in the wing disc during the late second or third instar contain significantly fewer cells than their wild-type sister clones. Fragments of DNA, indicative of cell death, are repeatedly seen in cells of the small clones. Clone size is substantially increased in fz^unspecified fz2^unspecified double mutant clones if they are also expressing BacA\p35^Scer\UAS.cHa under the control of Scer\GAL4^αTub84B.PL.

(Johnston and Sanders, 2003)

Loss of ft function in large or small clones does not alter the characteristic polarity of fz^unspecified mutant wings.

(Ma et al., 2003)

The domineering nonautonomy of fz^unspecified clones is enhanced by ds^UAO71/ds^33k.

(Adler et al., 1998)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Rescued by

fz^unspecified is rescued by fz^arm.EGFP

(Strutt, 2001)

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (3)

Reported As

Symbol Synonym

fz^-

(Lawrence et al., 2004)

fz^unspecified

unspecified

(Wong and Adler, 1993)

Name Synonyms

Secondary FlyBase IDs

References (16)

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