FB2024_03 , released June 25, 2024
Allele: Dmel\vri5R7.2
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General Information
Symbol
Dmel\vri5R7.2
Species
D. melanogaster
Name
FlyBase ID
FBal0063684
Feature type
allele
Associated gene
Dmel\vri
Associated Insertion(s)
P{5'lacW.5R7.2}vri5R7.2
Carried in Construct
Key Links
Allele class
Mutagen
Nature of the Allele
Allele class
Mutagen
Delta2-3 transposase
(George and Terracol, 1997)
P-element activity
(Szuplewski et al., 2003)
Progenitor genotype
vrik05901
(Szuplewski et al., 2003, George and Terracol, 1997)
Associated Insertion(s)
P{5'lacW.5R7.2}vri5R7.2
Cytology
Description

Imprecise excision of the P{lacW} element, resulting in a deletion of genomic DNA extending from the 3' end of the element. The deletion removes 7627bp from the P{lacW} transposon 3' end and 3735bp in vri.

(Szuplewski et al., 2003)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      7% of stage 11-13 homozygous embryos show tracheal defects. During stages 14-17, 72% of homozygous embryos show weak tracheal defects (the general architecture of the trachea is preserved, but breaking of branches occurs and elongation and branching are abnormal) and 8% show strong tracheal defects (the tracheal architecture is strongly affected with complete disorganization and formation of sacs).

      54% of stage 11-13 vri2/vri5R7.2 embryos show tracheal defects. During stages 14-17, 76% of vri2/vri5R7.2 embryos show weak tracheal defects (the general architecture of the trachea is preserved, but breaking of branches occurs and elongation and branching are abnormal) and 12% show strong tracheal defects (the tracheal architecture is strongly affected with complete disorganization and formation of sacs).

      (Szuplewski et al., 2010)

      Bristles in homozygous clones are thinner and reduced in size than normal or are missing. The average distance between stout bristles of the triple row is reduced compared to wild type in homozygous clones, which is characteristic of smaller cells. There are holes in the margin due to atrophic or missing bristles. Mosaic flies in which the eyes are homozygous for vri5R7.2 have smaller eyes than normal and the eyes are rough. The ommatidia are disorganised and are spherical rather than the normal hexagonal shape and interommatidial bristles are missing or atrophic. The mean number of ommatidia is reduced by 19% compared to wild type and the mean size of the ommatidia is 80 +/- 9% of wild type. The photoreceptor stalks are twisted and shorter than normal.

      (Szuplewski et al., 2003)

      Homozygous embryos are shortened and the dorsal epidermis often appears wrinkled and reduced (leading to a slight 'tail-up' phenotype) and trachea are interrupted. Less frequently the head skeleton is abnormal and ventral denticles are fused or missing. Hemizygotes die as larvae.

      (George and Terracol, 1997)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Other
      Phenotype Manifest In
      Enhancer of
      Statement
      Reference

      vri5R7.2 is an enhancer of phenotype of dpphr4

      (George and Terracol, 1997)

      vri5R7.2 is an enhancer of phenotype of dpphr27

      (George and Terracol, 1997)

      vri5R7.2 is an enhancer of phenotype of ea161.13

      (George and Terracol, 1997)
      Other
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      vri5R7.2 kst01318 double heterozygotes have missing hairs at the anterior margin and notching at the posterior margin of the wing. vri5R7.2 ActnG0077 double heterozygotes have missing hairs at the anterior wing margin and on the wing surface.

      (Szuplewski et al., 2003)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (1)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      vri5R7.2
      (Szuplewski et al., 2010)
      ΔR7.2
      (Szuplewski et al., 2003)
      Name Synonyms
      Secondary FlyBase IDs
        References (3)