FB2024_03 , released June 25, 2024
Allele: Dmel\slmb1
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General Information
Symbol
Dmel\slmb1
Species
D. melanogaster
Name
FlyBase ID
FBal0083750
Feature type
allele
Associated gene
Dmel\slmb
Associated Insertion(s)
Carried in Construct
Also Known As
slimb1, slimb1
Key Links
Genomic Maps

Allele class

hypomorphic allele - genetic evidence

Mutagen
Nature of the Allele
Allele class

hypomorphic allele - genetic evidence

(Muzzopappa and Wappner, 2005, Jiang and Struhl, 1998)
Mutagen
ethyl methanesulfonate
(Jiang and Struhl, 1998)
Progenitor genotype
Cytology
Description

Amino acid replacement: S391L.

(Skwarek et al., 2014)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
point_mutation
3R:21,121,568..21,121,568 [-]
Nucleotide change:

C21121568T

Amino acid change:

S391L | slmb-PA; S391L | slmb-PB; S391L | slmb-PC

Reported amino acid change:

S391L

Comment:

Site of nucleotide substitution in mutant inferred by FlyBase based on reported amino acid change.

(Skwarek et al., 2014)
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      No neoplastic transformation is seen in slmb1 mutant wing disc clones.

      (Skwarek et al., 2014)

      Homozygous clones in the wing induce the formation of supernumerary wings. Within the supernumerary wing, the homozygous cells form ectopic vein 3. Vein structures within the supernumerary wing are often incomplete.

      (Wang et al., 1999)

      slmb1/slmb2 transheterozygotes carrying a single copy of slmbαTub84B.PJ are viable and show normal morphology, 5-10% of adults exhibit duplication of the haltere. Cells of clones proliferate normally and cause a repertoire of phenotypes characteristic of ectopic activation of the hh signalling pathway. Clone in the wing generate supernumerary 'double-anterior' wings and clones in the foreleg generate supernumerary forelegs composed of mirror-symmetric anterior structures. slmb1/slmb2 and slmb1/slmb00295 transheterozygotes and heterozygotes with Df(3R)e-R1 are pupal lethal.

      (Jiang and Struhl, 1998)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Other
      Statement
      Reference

      slmb1, smo3 has wing phenotype

      (Jiang and Struhl, 1998)
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      smo3; slmb1/slmb2 clones generate a supernumerary 'double-anterior' wing.

      (Jiang and Struhl, 1998)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Rescued by

      slmb2/slmb1 is rescued by slmbαTub84B.PJ

      (Jiang and Struhl, 1998)
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (3)
      References (14)