FlyBase Allele Report: Dmel\scb[Vol-2]

General Information

Symbol

Dmel\scb^Vol-2

Species

D. melanogaster

Name

FlyBase ID

FBal0083756

Feature type

allele

Associated gene

Dmel\scb

Associated Insertion(s)

Carried in Construct

Also Known As

vol²

Key Links

Allele class

Mutagen

Delta2-3 transposase

Nature of the Allele

Allele class

Mutagen

Delta2-3 transposase

(Grotewiel et al., 1998)

Progenitor genotype

Cytology

Description

Imprecise excision causing a deletion of 816 nucleotides of genomic sequence that removes the first exon of scb short.

(Grotewiel et al., 1998)

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal learning | dominant

(Beck et al., 2000)

abnormal learning | semidominant

(Beck et al., 2000)

abnormal memory

(Tamura et al., 2003)

abnormal memory | dominant

(Grotewiel et al., 1998)

abnormal neurophysiology

(Rohrbough et al., 2000)

viable

(Rohrbough et al., 2000)

Phenotype Manifest In

Detailed Description

Statement

Reference

Mutant animals show reduced 1 hour memory and normal age-related memory impairment.

(Tamura et al., 2003)

Single-trial short program training in an olfactory learning assay shows that scb^Vol-1 flies perform poorly immediately after conditioning. Single-trial training fails to induce any conditioning whatsoever. The scb^Vol-2 allele is partially dominant for performance after single-trial and two-trial massed conditioning. The scb^Vol-2 phenotype after two massed trials or two spaced trials is completely dominant.

(Beck et al., 2000)

At physiological levels of external Ca²⁺ mutant nmjs show normal transmission. At reduced external Ca²⁺ levels EJC amplitudes are increased over those of controls (least pronounced for scb^Vol-2, but highly significant for scb^Vol-1, scb^Vol-3 and scb^Vol-4. scb^Vol-2 shows normal dependence on external Ca²⁺. Mutants show normal augmentation of transmission amplitude upon prolonged stimulation at intermediate frequencies, but a dramatic decrease in transmission amplitude after tetanus, compared to wild type.

(Rohrbough et al., 2000)

Mutations produce a memory deficit as shown in the odour avoidance test. Neither sensorimotor nor gross anatomical defects can account for the memory deficit. Conditional expression of scb short just before behavioural training is sufficient to fully rescue the memory deficit. Rescue is completely reversible.

(Grotewiel et al., 1998)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Enhancer of

Statement

Reference

scb^Vol-2/scb[+] is an enhancer of visible | dominant phenotype of sog^EP7

(Araujo et al., 2003)

scb^Vol-2/scb[+] is an enhancer of visible | dominant phenotype of sog^EP11

(Araujo et al., 2003)

Phenotype Manifest In

Enhancer of

Statement

Reference

scb^Vol-2/scb[+] is an enhancer of wing vein phenotype of sog^EP7

(Araujo et al., 2003)

scb^Vol-2/scb[+] is an enhancer of wing vein phenotype of sog^EP11

(Araujo et al., 2003)

Additional Comments

Genetic Interactions

Statement

Reference

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Rescued by

scb^Vol-2 is rescued by scb^s.hs

(Beck et al., 2000)

scb^Vol-2 is rescued by scb^s.hs

(Grotewiel et al., 1998)

Comments

Images (0)

Mutant

Wild-type

Stocks (1)

Bloomington

9408

scb^Vol-2/CyO

Notes on Origin

Discoverer

Comments

Mutation disrupts the expression of scb short form.

(Grotewiel et al., 1998)

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (4)

Reported As

Symbol Synonym

Vol²

(Beck et al., 2000, Rohrbough et al., 2000, Grotewiel et al., 1998)

scb^Vol-2

vol¹

(Tamura et al., 2003)

vol²

(Araujo et al., 2003)

Name Synonyms

Secondary FlyBase IDs

References (5)

Report Sections

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