FlyBase Allele Report: Dmel\scb[Vol-1]

General Information

Symbol

Dmel\scb^Vol-1

Species

D. melanogaster

Name

FlyBase ID

FBal0083757

Feature type

allele

Associated gene

Dmel\scb

Associated Insertion(s)

P{lArB}scb^Vol-1

Carried in Construct

Also Known As

vol¹

Key Links

Allele class

Mutagen

P-element activity

Nature of the Allele

Allele class

Mutagen

P-element activity

(Grotewiel et al., 1998)

Progenitor genotype

Associated Insertion(s)

P{lArB}scb^Vol-1

Cytology

Description

Insertion within the first intron of scb long RNA and within the 5' flanking region of scb short mRNA.

(Grotewiel et al., 1998)

Allele components

Component

Use(s)

Inserted element

P{lArB}

enhancer trap

Encoded product / tool

lacZ

reporter enzyme

Tagged with

Tag:NLS(P)

nuclear protein localization tag

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal learning | recessive

(Beck et al., 2000)

abnormal memory

(Tamura et al., 2003)

abnormal memory | dominant

(Grotewiel et al., 1998)

abnormal neurophysiology

(Rohrbough et al., 2000)

viable

(Rohrbough et al., 2000)

Phenotype Manifest In

Detailed Description

Statement

Reference

Mutant animals show reduced 1 hour memory and normal age-related memory impairment.

(Tamura et al., 2003)

Single-trial short program training in an olfactory learning assay shows that scb^Vol-1 flies perform poorly immediately after conditioning. The mutants are sensitive to two-trial, spaced conditioning over two-trial, massed conditioning, behaving in this respect qualitatively like control flies. The phenotype after short program training is completely recessive.

(Beck et al., 2000)

At physiological levels of external Ca²⁺ mutant nmjs show normal transmission. At reduced external Ca²⁺ levels EJC amplitudes are increased over those of controls (least pronounced for scb^Vol-2, but highly significant for scb^Vol-1, scb^Vol-3 and scb^Vol-4. scb^Vol-1, scb^Vol-3 and scb^Vol-4 show reduced slope of the logarithmic relationship between EJC amplitude and external Ca²⁺ concentration, indicating reduced Ca²⁺ dependence of transmission. Mutants show significant defects in two forms of short-term facilitation, paired pulse and frequency dependent short term facilitation. Mutants show impaired augmentation of transmission amplitude upon prolonged stimulation at intermediate frequencies.

(Rohrbough et al., 2000)

Mutations produce a memory deficit as shown in the odour avoidance test. Neither sensorimotor nor gross anatomical defects can account for the memory deficit.

(Grotewiel et al., 1998)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Enhancer of

Statement

Reference

scb[+]/scb^Vol-1 is an enhancer of visible | dominant phenotype of sog^EP7

(Araujo et al., 2003)

scb[+]/scb^Vol-1 is an enhancer of visible | dominant phenotype of sog^EP11

(Araujo et al., 2003)

Phenotype Manifest In

Enhancer of

Statement

Reference

scb[+]/scb^Vol-1 is an enhancer of wing vein phenotype of sog^EP7

(Araujo et al., 2003)

scb[+]/scb^Vol-1 is an enhancer of wing vein phenotype of sog^EP11

(Araujo et al., 2003)

Additional Comments

Genetic Interactions

Statement

Reference

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

Comments

Mutation disrupts the expression of scb long form.

(Grotewiel et al., 1998)

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (5)

Reported As

Symbol Synonym

Vol¹

(Beck et al., 2000, Rohrbough et al., 2000)

scb^Vol-1

vol¹

(Yamazaki et al., 2007, Araujo et al., 2003)

vol²

(Tamura et al., 2003)

Name Synonyms

Line 1,116

(Grotewiel et al., 1998)

Secondary FlyBase IDs

References (6)

Report Sections

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