FB2024_03 , released June 25, 2024
Allele: Dmel\cortoUAS.cKa
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General Information
Symbol
Dmel\cortoUAS.cKa
Species
D. melanogaster
Name
Saccharomyces cerevisiae UAS construct a of Kodjabachian
FlyBase ID
FBal0086675
Feature type
allele
Associated gene
Dmel\corto
Associated Insertion(s)
Carried in Construct
P{UAS-corto.K}
Key Links
Transgenic product class
cDNA
(Kodjabachian et al., 1998)
wild_type
(Kodjabachian et al., 1998)
Mutagen
Nature of the Allele
Transgenic product class
cDNA
(Kodjabachian et al., 1998)
wild_type
(Kodjabachian et al., 1998)
Mutagen
in vitro construct
(Kodjabachian et al., 1998)
Progenitor genotype
Carried in construct
P{UAS-corto.K}
Cytology
Description

A cDNA fragment encompassing the entire corto coding region is expressed under the control of UASt regulatory sequences.

(Kodjabachian et al., 1998)
Allele components
Component
Use(s)
Regulatory region(s)
UASt
Encoded product / tool
corto
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Expression of cortoUAS.cKa under the control of either Scer\GAL4Bx-MS1096 or Scer\GAL4sd.PU leads to induction of extra pieces of wing vein tissue in all flies.

      When cortoUAS.cKa is expressed under the control of Scer\GAL4hs.PB, the highest percentage of ectopic vein phenotype is obtained as a result of heat-shock applied between 96 to 120 hours after egg laying (AEL) as compared to no heat-shock, heat-shock applied between 72 h-96 h AEL or 120 h-136 h AEL conditions.

      (Mouchel-Vielh et al., 2011)

      Most animals expressing cortoScer\UAS.cKa under the control of Scer\GAL4ptc-559.1 differentiate into adults. 100% of these flies show a transformation of arista towards tarsal segments of the leg, with most of the transformed legs including the distal-most tarsal structures (the tuft and the claw). There is also a fully penetrant weak transformation of halteres to wings. Flies have rotated genitalia and show loss of scutellar bristles. A gradual reduction in the size of the legs, wing blades and scutellum is seen as the temperature increases.

      (Kodjabachian et al., 1998)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (3)
      Reported As
      Symbol Synonym
      cortoScer\UAS.cKa
      cortoUAS.cKa
      Name Synonyms
      Saccharomyces cerevisiae UAS construct a of Kodjabachian
      (Kodjabachian et al., 1998)
      Secondary FlyBase IDs
        References (3)