FB2024_03 , released June 25, 2024
Allele: Dmel\chic35A
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General Information
Symbol
Dmel\chic35A
Species
D. melanogaster
Name
FlyBase ID
FBal0086691
Feature type
allele
Associated gene
Dmel\chic
Associated Insertion(s)
P{lacW}chic35A
Carried in Construct
Key Links
Genomic Maps

Allele class
Mutagen
Nature of the Allele
Allele class
Mutagen
P-element activity
(Giansanti et al., 1998)
Progenitor genotype
Associated Insertion(s)
P{lacW}chic35A
Cytology
Description

Insertion of a P{lacW} element within the first intron.

(Giansanti et al., 1998)
Allele components
Component
Use(s)
Inserted element
P{lacW}
Encoded product / tool
lacZ
Tagged with
Tag:NLS(P)
Mutations Mapped to the Genome
Curation Data
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In

      aster & meiotic cell cycle | male

      (Giansanti et al., 1998)

      contractile ring & meiotic cell cycle | male

      (Giansanti et al., 1998)

      onion stage spermatid

      (Giansanti et al., 1998)

      spermatocyte

      (Giansanti et al., 1998)

      spindle & meiotic cell cycle | male

      (Giansanti et al., 1998)
      Detailed Description
      Statement
      Reference

      Homozygous adults have normal bristles. Female fertile in transheterozygous combination with chic8A. Onion-stage spermatids usually contain a single Nebenkern of larger than normal size, associated with two or more normal-sized nuclei (57.4% of spermatids have 4 nuclei). Approximately 3% of primary spermatocytes are polyploid. The central spindle is severely defective in the first meiotic division in homozygous males, and the actin-based contractile ring is missing. 60% of asters show irregular positioning and delayed migration during meiotic divisions in homozygous males.

      (Giansanti et al., 1998)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      Comments
      Comments

      Precise excision of the P{lacW} element results in reversion of the mutant phenotype.

      (Giansanti et al., 1998)
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      chi35A
      chic35A
      Name Synonyms
      Secondary FlyBase IDs
        References (2)