profilin, sand, stranded, chi, chicadee
profilin homolog - regulates polymerization of the actin cytoskeleton - chickadee/profilin mRNA is a direct and functional target of the RNA-binding protein Imp that localizes to axons and controls axonal regrowth of mushroom body γ neurons
Please see the JBrowse view of Dmel\chic for information on other features
To submit a correction to a gene model please use the Contact FlyBase form
AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.
Gene model reviewed during 5.40
Annotated transcripts do not represent all supported alternative splices within 5' UTR.
Low-frequency RNA-Seq exon junction(s) not annotated.
Gene model reviewed during 5.44
1.2, 1.0 (northern blot)
126 (aa)
Occurs in many kinds of cells as a complex with monomeric actin in a 1:1 ratio.
Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\chic using the Feature Mapper tool.
The testis specificity index was calculated from modENCODE tissue expression data by Vedelek et al., 2018 to indicate the degree of testis enrichment compared to other tissues. Scores range from -2.52 (underrepresented) to 5.2 (very high testis bias).
JBrowse - Visual display of RNA-Seq signals
View Dmel\chic in JBrowsePlease Note FlyBase no longer curates genomic clone accessions so this list may not be complete
Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see JBrowse for alignment of the cDNAs and ESTs to the gene model.
For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.
monoclonal
Identified in an RNAi screen for host factors that alter infection of SL2 cells by M.fortuitum.
dsRNA directed against this gene causes defects in cytokinesis when tested in an RNAi screen in S2 cells.
dsRNA made from templates generated with primers directed against this gene is tested in an RNAi screen for effects on actin-based lamella formation.
chic regulates actin filament formation throughout the cell cortex in the follicular epithelium.
Mutations in chic disrupt cytokinesis during male meiosis, preventing the formation of both the central spindle and the contractile ring.
Identification: Enhancer trap screen designed to discover genes involved in the cellular aspects of defense mechanisms, as well as in melanotic tumor formation processes linked to blood cell dysregulation.
Phenotypic analysis of chic male-sterile alleles reveals defects in meiotic cytokinesis and suggests that proper actin assembly is necessary for centrosome separation and migration.
Induced expression of chic proteins causes aberrant cell shapes reflecting defects in cytokinesis and/or cel shape maintenance.
Proliferation defect locus.
Identification: Screen for mutations affecting neuromuscular connectivity, using an antibody to Fas2.
The network of cytoplasmic actin filaments in each nurse cell is missing in chic egg chambers: this does not account for the chic phenotype. Cytoplasm transport is disrupted as nuclei are not properly held in position during chic nurse cell regression and when flow starts the nuclei are pushed into the ring canals thus blocking the pathway to the oocyte.
There are at least 10 P element insertions at chic with effects on both male and female fertility and bristle formation. Female sterile mutation caused by loss of ovary specific transcript. P insert in first exon.
Promotes actin assembly.
Mutations at the chic locus cause defects in midoogenesis.
