FlyBase Allele Report: Dmel\chic[UAS.cCa]

General Information

Symbol

Dmel\chic^UAS.cCa

Species

D. melanogaster

Name

Saccharomyces cerevisiae UAS construct a of Cooley

FlyBase ID

FBal0159404

Feature type

allele

Associated gene

Dmel\chic

Associated Insertion(s)

Carried in Construct

P{UAS-chic.C}

Also Known As

UAS-chic, UAS-chickadee

Key Links

Transgenic product class

wild_type

(Geisbrecht and Montell, 2004)

Mutagen

in vitro construct

Nature of the Allele

Transgenic product class

wild_type

(Geisbrecht and Montell, 2004)

Mutagen

in vitro construct

(Geisbrecht and Montell, 2004)

Progenitor genotype

Carried in construct

P{UAS-chic.C}

Cytology

Description

UAS regulatory sequences drive expression of chic.

(Geisbrecht and Montell, 2004)

Allele components

Component

Use(s)

Regulatory region(s)

UAS

binary expression system - regulatory region

Encoded product / tool

chic

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal neuroanatomy, with Scer\GAL4^P2.4.Pdf

(Reeve et al., 2005)

Phenotype Manifest In

adult abdomen, with Scer\GAL4^NP5130

(Ninov et al., 2007)

embryonic epidermis, with Scer\GAL4^fkh.PH

(Maybeck and Röper, 2009)

histoblast nest, with Scer\GAL4^NP5130

(Ninov et al., 2007)

LNv neuron, with Scer\GAL4^P2.4.Pdf

(Reeve et al., 2005)

ventral adult lateral neuron & commissure, with Scer\GAL4^P2.4.Pdf

(Reeve et al., 2005)

Detailed Description

Statement

Reference

Expression of chic^Scer\UAS.cCa under the control of Scer\GAL4^e22c has no effect on wound closure.

(Brock et al., 2012)

Expression via Scer\GAL4^fkh.PH leads to embryos showing a disorganized epidermis (in regions of Scer\GAL4^fkh.PH expression). The salivary glands nonetheless invaginate.

(Maybeck and Röper, 2009)

Expression of chic^Scer\UAS.cCa under the control of Scer\GAL4^esg-NP5130 causes the inefficient expansion of histoblast nests, provoking abdominal clefts. chic^Scer\UAS.cCa-overexpressing histoblasts lack the numerous long actin protrusions formed during expansion in wild-type cells, and instead exhibit rare short filopodia and lamellipodia. The transition of histoblast nests from pseudostratified epithelia to an unstratified monolayer is delayed in animals of this genotype.

(Ninov et al., 2007)

In the brains of flies expressing chic^Scer\UAS.cCa, under the control of Scer\GAL4^P2.4.Pdf, the LNv innervation covers a target area that is significantly larger than in wild-type brains. Additionally, the posterior tract of the LNv neurons shows a defasciculation phenotype in ~48% of these flies.

(Reeve et al., 2005)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Suppressed by

Statement

Reference

Scer\GAL4^P2.4.Pdf, chic^UAS.cCa has abnormal neuroanatomy phenotype, suppressible by Fmr1^UAS.cZa, Scer\GAL4^P2.4.Pdf

(Reeve et al., 2005)

Suppressor of

Statement

Reference

Scer\GAL4^GMR71G10/chic^UAS.cCa is a suppressor of abnormal neuroanatomy | somatic clone | adult stage phenotype of ena^Δ151

(Yaniv et al., 2020)

Scer\GAL4^Tab2-201Y/chic^UAS.cCa is a suppressor | partially of abnormal neuroanatomy | somatic clone | adult stage phenotype of Imp⁷

(Medioni et al., 2014)

chic^UAS.cCa/Scer\GAL4^P2.4.Pdf is a suppressor of abnormal neuroanatomy phenotype of Fmr1^UAS.cZa, Scer\GAL4^c747

(Reeve et al., 2005)

chic^UAS.cCa, Scer\GAL4^c747 is a suppressor of abnormal neuroanatomy phenotype of Fmr1^UAS.cZa, Scer\GAL4^c747

(Reeve et al., 2005)

NOT Suppressor of

Statement

Reference

Scer\GAL4^GMR71G10/chic^UAS.cCa is a non-suppressor of abnormal neuroanatomy | somatic clone | adult stage phenotype of DAAM^ΔORF, ena^Δ151

(Yaniv et al., 2020)

Phenotype Manifest In

Suppressed by

Statement

Reference

Scer\GAL4^P2.4.Pdf, chic^UAS.cCa has ventral adult lateral neuron & commissure phenotype, suppressible by Fmr1^UAS.cZa, Scer\GAL4^P2.4.Pdf

(Reeve et al., 2005)

Scer\GAL4^P2.4.Pdf, chic^UAS.cCa has LNv neuron phenotype, suppressible by Fmr1^UAS.cZa, Scer\GAL4^P2.4.Pdf

(Reeve et al., 2005)

Suppressor of

Statement

Reference

Scer\GAL4^GMR71G10/chic^UAS.cCa is a suppressor of adult mushroom body gamma-lobe | somatic clone phenotype of ena^Δ151

(Yaniv et al., 2020)

Scer\GAL4^GMR71G10/chic^UAS.cCa is a suppressor of axon | somatic clone | adult stage phenotype of ena^Δ151

(Yaniv et al., 2020)

Scer\GAL4^Tab2-201Y/chic^UAS.cCa is a suppressor | partially of gamma Kenyon cell | somatic clone | adult stage phenotype of Imp⁷

(Medioni et al., 2014)

chic^UAS.cCa, Scer\GAL4^c747 is a suppressor of adult mushroom body phenotype of Fmr1^UAS.cZa, Scer\GAL4^c747

(Reeve et al., 2005)

chic^UAS.cCa/Scer\GAL4^P2.4.Pdf is a suppressor of LNv neuron phenotype of Fmr1^UAS.cZa, Scer\GAL4^c747

(Reeve et al., 2005)

chic^UAS.cCa, Scer\GAL4^slbo.2.6 is a suppressor | partially of border follicle cell phenotype of Rac1^N17.UAS, Scer\GAL4^slbo.2.6

(Geisbrecht and Montell, 2004)

NOT Suppressor of

Statement

Reference

Scer\GAL4^GMR71G10/chic^UAS.cCa is a non-suppressor of adult mushroom body gamma-lobe | somatic clone phenotype of DAAM^ΔORF, ena^Δ151

(Yaniv et al., 2020)

Scer\GAL4^GMR71G10/chic^UAS.cCa is a non-suppressor of axon | somatic clone | adult stage phenotype of DAAM^ΔORF, ena^Δ151

(Yaniv et al., 2020)

Additional Comments

Genetic Interactions

Statement

Reference

Scer\GAL4^Tab2-201Y-mediated expression of chic^Scer\UAS.cCa significantly suppresses the γ axon growth phenotype of Imp⁷ mutant neurons.

(Medioni et al., 2014)

Flies that co-express chic^Scer\UAS.cCa and Fmr1^Scer\UAS.cZa, both under the control of Scer\GAL4^P2.4.Pdf, show a wild-type-like pattern of LNv innervation. The LNv fasciculation phenotype seen when chic^Scer\UAS.cCa is expressed alone is suppressed. Coexpression of chic^Scer\UAS.cCa significantly reduces the mushroom body phenotype seen when flies overexpress Fmr1^Scer\UAS.cZa under the control of Scer\GAL4^c747.

(Reeve et al., 2005)

The border follicle cell migration defect seen in egg chambers expressing Rac1^N17.Scer\UAS under the control of Scer\GAL4^slbo.2.6 is partially suppressed by coexpression of chic^Scer\UAS.cCa.

(Geisbrecht and Montell, 2004)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Rescues

Scer\GAL4^GMR71G10/chic^UAS.cCa rescues chic^Δ29-33

(Yaniv et al., 2020)

Scer\GAL4^e22c/chic^UAS.cCa rescues chic^NIG.9553R

(Brock et al., 2012)

Comments

Co-expression of chic^Scer\UAS.cCa partially suppresses the failure of wound closure seen in larvae expressing chic^NIG.9553R under the control of Scer\GAL4^e22c.

(Brock et al., 2012)

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

L. Cooley

(Geisbrecht and Montell, 2004)

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (3)

Reported As

Symbol Synonym

chic^Scer\UAS.cCa

chic^UAS.cCa

Name Synonyms

Saccharomyces cerevisiae UAS construct a of Cooley

(Geisbrecht and Montell, 2004)

Secondary FlyBase IDs

References (13)

Report Sections

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