FlyBase Allele Report: Scer\GAL4[c747]

Adult expression is observed weakly in a subset of antennal glomeruli, and more strongly in fibers in the antennomechanosensory tract, subsets of Kenyon cells in the lobes, calyx, and peduncle of the mushroom body, and in the central part of the median bundle. The ellipsoid body is labeled in most domains, possibly from R1 and R4 type ring neurons. A middle layer of the fan-shaped body is faintly labeled from a lateral type large field tangential neuron. Representative images can be seen Figures 4 and 5 of FBrf0127414.

(Zars et al., 2000)

Expression is highest in the mushroom bodies, but is generally widespread.

(Waddell et al., 2000)

ScerGAL4^c747 expresses within a group of neurons connecting the tip of the gamma-lobe to the rostral area of the medial protocerebrum. It also expresses extensively throughout the adult central brain neuropil.

(Armstrong et al., 1998)

In late third instar larva, expressed in discrete spots in wing and legs discs; expressed in central brain and ventral ganglion.

(Manseau et al., 1997)

Expression in adult brain primarily in corpora pedunculata (mushroom body).

(Connolly et al., 1996)

Marker for

Kenyon cell

(Zars et al., 2000)

adult median bundle

(Zars et al., 2000)

mushroom body

(Zars et al., 2000)

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal behavior | heat sensitive, with shi^1.UAS

(Pitman et al., 2006)

abnormal courtship behavior, with shi^1.UAS

(Broughton et al., 2004)

abnormal courtship behavior | male | heat sensitive, with shi^1.UAS

(Sakai and Kitamoto, 2006)

abnormal learning, with Btau\MAPT^UAS.cKa

(Mershin et al., 2004)

abnormal learning, with Dop1R1^UAS.cLa

(Liu et al., 2009)

abnormal learning, with drk^RNAi.Sym.UAS

(Moressis et al., 2009)

abnormal learning, with Gαs^Q215L.UAS

(Connolly et al., 1996)

abnormal learning, with Hsap\MAPT^UAS.cWa

(Mershin et al., 2004)

abnormal learning, with Ras85D^V12.UAS

(Moressis et al., 2009)

abnormal learning, with Rdl^RNAi.2-7.UAS

(Liu et al., 2009)

abnormal learning, with Rdl^RNAi.4-5.UAS

(Liu et al., 2009, Liu et al., 2007)

abnormal learning, with Rdl^{RNAi.8-10.UAS}

(Liu et al., 2009, Liu et al., 2007)

abnormal learning, with Rdl^UAS.cLa

(Liu et al., 2009, Liu et al., 2007)

abnormal learning, with tau^UAS.cMa

(Mershin et al., 2004)

abnormal learning | adult stage, with Fmr1^GD1288

(Kanellopoulos et al., 2012)

abnormal learning | adult stage | heat sensitive, with Rdl^UAS.cLa, Scer\GAL80^ts.αTub84B

(Liu et al., 2007)

abnormal learning | heat sensitive, with shi^1.UAS

(Dubnau et al., 2001)

abnormal locomotor behavior, with shi^1.UAS

(Broughton et al., 2004)

abnormal locomotor behavior | adult stage | heat sensitive, with shi^1.UAS

(Sakai and Kitamoto, 2006)

abnormal medium-term memory | adult stage, with Argk1^GD10436

(Bozzato et al., 2020)

abnormal memory, with 2mit^RNAi.UAS.cBa

(Baggio et al., 2013)

abnormal memory, with Bper\ptxA^act.UAS

(Ferris et al., 2006)

abnormal memory, with Btau\MAPT^UAS.cKa

(Mershin et al., 2004)

abnormal memory, with Fmr1^RNAi.280.UAS

(Bolduc et al., 2008)

abnormal memory, with Fmr1^RNAi.500.UAS

(Bolduc et al., 2008)

abnormal memory, with Hsap\MAPT^UAS.cWa

(Mershin et al., 2004)

abnormal memory, with mir-276a^{sponge.UAS.EGFP}

(Li et al., 2013)

abnormal memory, with N^RNAi.P.UAS

(Presente et al., 2004)

abnormal memory, with neur^{ΔRING.UAS.EGFP}

(Pavlopoulos et al., 2008)

abnormal memory, with pain^RNAi.UAS

(Sakai et al., 2012)

abnormal memory, with Scer\GAL80^ts.αTub84B, neur^UAS.cPa

(Pavlopoulos et al., 2008)

abnormal memory, with scrib^KK106065

(Cervantes-Sandoval et al., 2016)

abnormal memory, with tau^UAS.cMa

(Mershin et al., 2004)

abnormal memory | adult stage, with DopEcR^KK111211

(Ishimoto et al., 2013)

abnormal memory | adult stage, with Fmr1^GD1288

(Kanellopoulos et al., 2012)

abnormal memory | adult stage, with Pka-C1^UAS.Tag:FLAG

(Yamazaki et al., 2014)

abnormal memory | adult stage, with Rac1^V12.UAS.cUa

(Gai et al., 2016)

abnormal memory | adult stage, with SLC22A^KK112539

(Gai et al., 2016)

abnormal memory | adult stage | heat sensitive, with shi^1.UAS

(Kirkhart and Scott, 2015)

abnormal memory | heat sensitive, with shi^1.UAS

(Schwaerzel et al., 2002, Dubnau et al., 2001)

abnormal memory | temperature conditional, with neur^UAS.cPa

(Pavlopoulos et al., 2008)

abnormal neuroanatomy, with Fmr1^UAS.cZa

(Reeve et al., 2005)

abnormal neurophysiology | heat sensitive, with shi^1.UAS

(Dubnau et al., 2001)

abnormal sleep, with Pka-R1^{BDK.UAS.Tag:HA}

(Crocker et al., 2010)

abnormal sleep | adult stage, with Nf1^KK101909

(Machado Almeida et al., 2021)

abnormal smell perception | heat sensitive, with shi^1.UAS

(McGuire et al., 2001)

abnormal song, with eag^DN.EKI.UAS

(Broughton et al., 2004)

abnormal song, with shi^1.UAS

(Broughton et al., 2004)

abnormal temperature response | adult stage, with Cyp6a17^RNAi.UAS.WIZ

(Kang et al., 2011)

bang sensitive, with kcc^HMS01058

(Rusan et al., 2014)

lethal, with Adf1^UAS.cDa

(DeZazzo et al., 2000)

paralytic, with kcc^HMS01058

(Rusan et al., 2014)

short lived, with PQBP1^RNAi.UAS

(Tamura et al., 2013)

viable, with Rdl^UAS.cLa

(Liu et al., 2007)

Phenotype Manifest In

adult mushroom body, with Fmr1^UAS.cZa

(Reeve et al., 2005)

adult mushroom body, with shi^1.UAS

(Dubnau et al., 2001)

Detailed Description

Statement

Reference

Inhibition (using shi^1.UAS at 32[o]C) of Scer\GAL4^c747 cells in adults during testing has no effect on the increase in aversive olfactory 24 h memory observed when the recall environment better matches the training environment (presence of copper grid), compared to controls.

(Zhao et al., 2019)

Inhibition (using shi^1.UAS at 32[o]C) of Scer\GAL4^c747 cells in adults significantly reduces 5 min (single-trial conditioned) and 30 min (multiple-trial conditioned) aversive taste memory, compared to controls.

(Kirkhart and Scott, 2015)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

NOT Enhanced by

Statement

Reference

Dop1R1^UAS.cLa, Scer\GAL4^c747 has abnormal learning phenotype, non-enhanceable by Rdl^RNAi.4-5.UAS, Scer\GAL4^c747

(Liu et al., 2009)

Suppressed by

Statement

Reference

Pka-C1^UAS.Tag:FLAG, Scer\GAL4^c747 has abnormal memory | adult stage phenotype, suppressible by Pcb^EP2547/PCB[+]

(Yamazaki et al., 2014)

Fmr1^UAS.cZa, Scer\GAL4^c747 has abnormal neuroanatomy phenotype, suppressible by chic^UAS.cCa, Scer\GAL4^c747

(Reeve et al., 2005)

Fmr1^UAS.cZa, Scer\GAL4^c747 has abnormal neuroanatomy phenotype, suppressible by chic^UAS.cCa/Scer\GAL4^P2.4.Pdf

(Reeve et al., 2005)

NOT Enhancer of

Statement

Reference

Rdl^RNAi.4-5.UAS, Scer\GAL4^c747 is a non-enhancer of abnormal learning phenotype of Dop1R1^UAS.cLa, Scer\GAL4^c747

(Liu et al., 2009)

Suppressor of

Statement

Reference

Scer\GAL4^c747/mGluR^GD707 is a suppressor of abnormal learning | dominant | adult stage phenotype of Fmr1³

(Kanellopoulos et al., 2012)

Scer\GAL4^c747/Rdl^{RNAi.8-10.UAS} is a suppressor of paralytic | recessive phenotype of kcc^DHS1

(Hekmat-Scafe et al., 2010)

Scer\GAL4^c747/Ncc69^GD14863 is a suppressor of paralytic | recessive phenotype of kcc^DHS1

(Hekmat-Scafe et al., 2010)

Scer\GAL4^c747/Ras85D^V12.S35.UAS is a suppressor of abnormal learning phenotype of drk^ΔP24

(Moressis et al., 2009)

Scer\GAL4^c747/Raf^UAS.F179 is a suppressor of abnormal learning phenotype of drk^ΔP24

(Moressis et al., 2009)

Scer\GAL4^c747/Raf^fl.UAS is a suppressor of abnormal learning phenotype of drk^e0A

(Moressis et al., 2009)

Scer\GAL4^c747/Raf^UAS.F179 is a suppressor of abnormal learning phenotype of drk^e0A

(Moressis et al., 2009)

chic^UAS.cCa, Scer\GAL4^c747 is a suppressor of abnormal neuroanatomy phenotype of Fmr1^UAS.cZa, Scer\GAL4^c747

(Reeve et al., 2005)

NOT Suppressor of

Statement

Reference

Scer\GAL4^c747/Alk^{EC.UAS.Tag:MYC} is a non-suppressor of abnormal learning | adult stage phenotype of Nf1^E1/Nf1^E2

(Gouzi et al., 2011)

Scer\GAL4^c747/Alk^GD42 is a non-suppressor of abnormal learning | adult stage phenotype of Nf1^E1/Nf1^E2

(Gouzi et al., 2011)

Scer\GAL4^c747/Rdl^RNAi.2-7.UAS is a non-suppressor of abnormal learning phenotype of rut¹

(Liu et al., 2009)

Scer\GAL4^c747/Rdl^RNAi.4-5.UAS is a non-suppressor of abnormal learning phenotype of rut¹

(Liu et al., 2009)

Scer\GAL4^c747/Rdl^{RNAi.8-10.UAS} is a non-suppressor of abnormal learning phenotype of rut²⁰⁸⁰

(Liu et al., 2009)

Scer\GAL4^c747, Scer\GAL80^ts.αTub84B, Ras85D^V12.S35.UAS is a non-suppressor of abnormal learning phenotype of drk^ΔP24

(Moressis et al., 2009)

Scer\GAL4^c747, Raf^UAS.F179, Scer\GAL80^ts.αTub84B is a non-suppressor of abnormal learning phenotype of drk^ΔP24

(Moressis et al., 2009)

Scer\GAL4^c747/Raf^UAS.F179 is a non-suppressor of abnormal memory phenotype of drk^ΔP24

(Moressis et al., 2009)

Scer\GAL4^c747/Raf^fl.UAS is a non-suppressor of abnormal memory phenotype of drk^ΔP24

(Moressis et al., 2009)

Phenotype Manifest In

Suppressed by

Statement

Reference

Fmr1^UAS.cZa, Scer\GAL4^c747 has LNv neuron phenotype, suppressible by chic^UAS.cCa/Scer\GAL4^P2.4.Pdf

(Reeve et al., 2005)

Fmr1^UAS.cZa, Scer\GAL4^c747 has adult mushroom body phenotype, suppressible by chic^UAS.cCa, Scer\GAL4^c747

(Reeve et al., 2005)

Suppressor of

Statement

Reference

chic^UAS.cCa, Scer\GAL4^c747 is a suppressor of adult mushroom body phenotype of Fmr1^UAS.cZa, Scer\GAL4^c747

(Reeve et al., 2005)

Additional Comments

Genetic Interactions

Statement

Reference

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Rescues

Scer\GAL4^c747/DopEcR^UAS.cIb rescues DopEcR^c02142

(Ishimoto et al., 2013)

Scer\GAL4^c747/Fmr1^UAS.cWa rescues Fmr1³

(Kanellopoulos et al., 2012)

Scer\GAL4^c747/Nf1^UAS.cBa rescues Nf1^c00617

(Buchanan and Davis, 2010)

Scer\GAL4^c747/Pka-C1^UAS.Tag:FLAG rescues Pka-C1^B3

(Horiuchi et al., 2008)

Scer\GAL4^c747/neur^UAS.cPa rescues neur¹

(Pavlopoulos et al., 2008)

Scer\GAL4^c747/orb2^A.UAS rescues orb2^ΔQ/orb2^Δ

(Keleman et al., 2007)

Scer\GAL4^c747/orb2^B.UAS rescues orb2^ΔQ/orb2^Δ

(Keleman et al., 2007)

Scer\GAL4^c747/spoon^UAS.cYa rescues spoon^P1

(Lu et al., 2007)

Scer\GAL4^c747/rut^UAS.cZa rescues rut²⁰⁸⁰

(McGuire et al., 2003)

Scer\GAL4^c747/rut^UAS.cZa rescues rut²⁰⁸⁰

(Zars et al., 2000)

Scer\GAL4^c747/rut^UAS.cZa rescues rut²⁰⁸⁰

(Zars et al., 2000)

Partially rescues

Scer\GAL4^c747/Pen^UASp.cGa partially rescues Pen^mbmB

(Serway et al., 2020)

Scer\GAL4^c747/dlg1^{S97N.UAS.EGFP} partially rescues dlg1^intol

(Maiya et al., 2012)

Scer\GAL4^c747/kcc^UAS.cHb partially rescues kcc^DHS1

(Hekmat-Scafe et al., 2010)

Fails to rescue

Scer\GAL4^c747/Pen^ΔIBB.UASp fails to rescue Pen^mbmB

(Serway et al., 2020)

Scer\GAL4^c747/Pen^3xSA.UASp fails to rescue Pen^mbmB

(Serway et al., 2020)

Scer\GAL4^c747/Pen^CASB-.UASp fails to rescue Pen^mbmB

(Serway et al., 2020)

Scer\GAL4^c747/Pen^DIM-.UASp fails to rescue Pen^mbmB

(Serway et al., 2020)

Scer\GAL4^c747/Pen^NLSB-.UASp fails to rescue Pen^mbmB

(Serway et al., 2020)

Scer\GAL4^c747/Pen^S37A.UASp fails to rescue Pen^mbmB

(Serway et al., 2020)

Scer\GAL4^c747/Pen^{S56A.UASp.cGa} fails to rescue Pen^mbmB

(Serway et al., 2020)

Scer\GAL4^c747/Pen^S98A.UASp fails to rescue Pen^mbmB

(Serway et al., 2020)

Scer\GAL4^c747/Pen^SNLSB-.UASp fails to rescue Pen^mbmB

(Serway et al., 2020)

Scer\GAL4^c747/dlg1^UAS.EGFP fails to rescue dlg1^intol

(Maiya et al., 2012)

Scer\GAL4^c747, Nf1^UAS.cWa, Scer\GAL80^ts.αTub84B fails to rescue Nf1^E1/Nf1^E2

(Gouzi et al., 2011)

Scer\GAL4^c747, Scer\GAL80^Mef2.mb247, Nf1^UAS.cBa fails to rescue Nf1^c00617

(Buchanan and Davis, 2010)

Scer\GAL4^c747/Hr78^UAS.Fa fails to rescue Hr78³/Hr78²

(Astle et al., 2003)

Scer\GAL4^c747/amn^UAS.cWa fails to rescue amn^X8

(Waddell et al., 2000)

Comments

Images (0)

Mutant

Wild-type

Stocks (3)

Bloomington

6494

w^*; P{GawB}c747

78784

w^*; P{GawB}c747; P{UAS-eCOPR2}3

Kyoto

108808

w^*; P{GawB}c747

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (6)

Reported As

Symbol Synonym

C747

(Kitamoto, 2002, DeZazzo et al., 2000)

GAL4^C747

GAL4^c747

GAL4^c772

Scer\GAL4^c747

Scer\GAL4^c772

Name Synonyms

Secondary FlyBase IDs

FBal0048790
FBal0058805
FBal0155845

References (90)

Report Sections

Open Close