FB2024_03 , released June 25, 2024
Allele: Dmel\Cyp6a17RNAi.UAS.WIZ
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General Information
Symbol
Dmel\Cyp6a17RNAi.UAS.WIZ
Species
D. melanogaster
Name
FlyBase ID
FBal0266056
Feature type
allele
Associated gene
Dmel\Cyp6a17
Associated Insertion(s)
Carried in Construct
P{UAS-Cyp6a17.RNAi.WIZ}
Key Links
Transgenic product class
RNAi_reagent
(Kang et al., 2011)
Mutagen
Nature of the Allele
Transgenic product class
RNAi_reagent
(Kang et al., 2011)
Mutagen
in vitro construct
(Kang et al., 2011)
Progenitor genotype
Carried in construct
P{UAS-Cyp6a17.RNAi.WIZ}
Cytology
Description

UAS regulatory sequences drive expression of an inverted repeat of a 222bp cDNA fragment of Cyp6a17.

(Kang et al., 2011)
Allele components
Component
Use(s)
Regulatory region(s)
UAS
Encoded product / tool
Cyp6a17
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Expression of Cyp6a17dsRNA.Scer\UAS.WIZ under the control of either Scer\GAL4elav.PU, Scer\GAL4ey-OK107, Scer\GAL4Mef2.247 or Scer\GAL4c747 results in a significantly reduced avoidance index for low temperature in a temperature preference behaviour assay compared to wild type.

      Expression of Cyp6a17dsRNA.Scer\UAS.WIZ under the control of either Scer\GAL4c290, Scer\GAL4Aph-4-c232 or Scer\GAL4Ilp2.215-3 has no significant effect on temperature preference behaviour.

      Flies expressing Cyp6a17dsRNA.Scer\UAS.WIZ under the control of Scer\GAL4Cyp6a17.MB show altered temperature preference behaviour compared to wild type: the avoidance indices for both high and low temperatures are significantly reduced compared to wild type.

      Flies expressing Cyp6a17dsRNA.Scer\UAS.WIZ under the control of Scer\GAL4Cyp6a17-SG show altered temperature preference behaviour.

      (Kang et al., 2011)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (3)
      Reported As
      Symbol Synonym
      Cyp6a17RNAi.UAS.WIZ
      Cyp6a17dsRNA.Scer\UAS.WIZ
      Cyp6a17dsRNA.UAS.WIZ
      Name Synonyms
      Secondary FlyBase IDs
        References (2)