Bolduc, F.V., Bell, K., Cox, H., Broadie, K.S., Tully, T. (2008). Excess protein synthesis in Drosophila Fragile X mutants impairs long-term memory. Nat. Neurosci. 11(10): 1143--1145.
FlyBase ID
FBrf0206065
Publication Type
Research paper
Abstract
We used Drosophila olfactory memory as a model to study the molecular basis of cognitive defects in Fragile X syndrome in vivo. We observed that fragile X protein was acutely required and interacted with argonaute1 and staufen in the formation of long-term memory. Occlusion of long-term memory formation in Fragile X mutants could be rescued by protein synthesis inhibitors, suggesting that excess baseline protein synthesis could negatively affect cognition.
