FB2024_03 , released June 25, 2024
Allele: Dmel\kstB1-14.1
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General Information
Symbol
Dmel\kstB1-14.1
Species
D. melanogaster
Name
FlyBase ID
FBal0090408
Feature type
allele
Associated gene
Dmel\kst
Associated Insertion(s)
Carried in Construct
Also Known As
kst14.1
Key Links
Allele class

loss of function allele

Mutagen
    Nature of the Allele
    Allele class

    loss of function allele

    (Thomas and Kiehart, 1995)
    Mutagen
    Progenitor genotype
    Cytology
    Description
    Mutations Mapped to the Genome
    Curation Data
    Type
    Location
    Additional Notes
    References
    Variant Molecular Consequences
    Associated Sequence Data
    DDBJ / EMBL / GenBank
    DNA sequence
    Protein sequence
     
    UniProtKB/Swiss-Prot
      UniProtKB/TrEMBL
        Expression Data
        Reporter Expression
        Additional Information
        Statement
        Reference
         
        Marker for
        Reflects expression of
        Reporter construct used in assay
        Human Disease Associations
        Disease Ontology (DO) Annotations
        Models Based on Experimental Evidence ( 0 )
        Disease
        Evidence
        References
        Modifiers Based on Experimental Evidence ( 0 )
        Disease
        Interaction
        References
        Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
         
        Disease-implicated variant(s)
         
        Phenotypic Data
        Phenotypic Class
        Phenotype Manifest In
        Detailed Description
        Statement
        Reference

        Most of the kst2/kstB1-14.1 mutant larvae die as larvae.

        (Lee and Thomas, 2011)

        Mutant embryos hatch, but mutant pupae are present at less than 10% of the expected number, suggesting that most individuals die as larvae. There seems to be little pupal lethality and kst mutants eclose 2-4 days behind their wild-type siblings. Adult escapers are very infertile and lay few eggs.

        (Thomas et al., 1998)

        Homozygotes generally die as larvae. Surviving adults have defects in the eyes, wings and tracheal system.

        (Thomas and Kiehart, 1995)
        External Data
        Interactions
        Show genetic interaction network for Enhancers & Suppressors
        Phenotypic Class
        Enhanced by
        Statement
        Reference

        kstB1-14.1/kst1 has lethal phenotype, enhanceable by crb11A22/crb[+]

        (Medina et al., 2002)

        kstB1-14.1/kst2 has lethal phenotype, enhanceable by crb11A22/crb[+]

        (Medina et al., 2002)
        Suppressed by
        Statement
        Reference

        kstB1-14.1/kst2 has lethal | larval stage phenotype, suppressible | partially by Pak[+]/Pak6

        (Lee and Thomas, 2011)
        Enhancer of
        Statement
        Reference

        kst[+]/kstB1-14.1 is an enhancer of visible phenotype of Scer\GAL4GMR.PFa, trioUAS.cBa

        (Lee and Thomas, 2011)
        Phenotype Manifest In
        Enhancer of
        Statement
        Reference

        kst[+]/kstB1-14.1 is an enhancer of eye phenotype of Scer\GAL4GMR.PFa, trioUAS.cBa

        (Lee and Thomas, 2011)
        Additional Comments
        Genetic Interactions
        Statement
        Reference

        Heterozygosity for kstB1-14.1 significantly enhances the rough-eye phenotype induced by overexpression of trioScer\UAS.cBa via Scer\GAL4GMR.PFa.

        kst2/kstB1-14.1 mutant larvae that are heterozygous for Pak6 survive longer than kst2/Df(3L)1226 controls.

        (Lee and Thomas, 2011)
        Xenogenetic Interactions
        Statement
        Reference
        Complementation and Rescue Data
        Comments
        Images (0)
        Mutant
        Wild-type
        Stocks (1)
        Notes on Origin
        Discoverer
        External Crossreferences and Linkouts ( 0 )
        Synonyms and Secondary IDs (5)
        Reported As
        Symbol Synonym
        kst3
        (Thomas and Kiehart, 1995)
        kst14.1
        (Bajur et al., 2019, Duan et al., 2018, Lee and Thomas, 2011, Zarnescu and Thomas, 1999)
        kst3
        kstB1-14.1
        l(3)B1-14.1
        (Thomas et al., 1998)
        Name Synonyms
        Secondary FlyBase IDs
        • FBal0064833
        References (7)