FB2024_03 , released June 25, 2024
Allele: Dmel\vas6356-001
Open Close
General Information
Symbol
Dmel\vas6356-001
Species
D. melanogaster
Name
FlyBase ID
FBal0091102
Feature type
allele
Associated gene
Dmel\vas
Associated Insertion(s)
Carried in Construct
Key Links
Genomic Maps

Allele class
Mutagen
Nature of the Allele
Allele class
Mutagen
ethyl methanesulfonate
(Tinker et al., 1998)
Progenitor genotype
Cytology
Description

Nonsense mutation in the third exon that is common to both vas and solo.

(Yan et al., 2010)

Amino acid replacement: W21term.

(Tinker et al., 1998)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
point_mutation
2L:15,068,520..15,068,520 [+]
Nucleotide change:

G15068520A

Amino acid change:

W21term | solo-PA; W21term | solo-PB; W21term | vas-PA; W21term | vas-PB; W21term | vas-PC

Comment:

G to A nucleotide change at the second or third position of the wild type Trp codon leads to a nonsense mutation (exact site of mutation unspecified). The mutation was annotated at the second base of the codon.

(Tinker et al., 1998)
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      vas6356-001/vas6356-005 and vas6356-001/Df(2L)b87e25 females are sterile. Eggs laid by vas6356-001/Df(2L)b87e25 females have ventralised eggshells and fused dorsal appendages.

      (Tinker et al., 1998)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      NOT Suppressor of
      Statement
      Reference

      vas6356-001/Df(2L)b87e25 is a non-suppressor of egg chorion phenotype of Scer\GAL4CY2, btl::Egfrλ.UAS

      (Tinker et al., 1998)
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      vas6356-001/Df(2L)b87e25 does not alter the dorsalised eggshell phenotype of eggs derived from females expressing btl::EgfrScer\UAS.T:λ\cI-DD under the control of Scer\GAL4CY2.

      vas6356-001/vas6356-005 does not alter the dorsalised eggshell phenotype of eggs derived from fs(1)K10unspecified females.

      (Tinker et al., 1998)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Fails to complement

      vas6356-005

      (Tinker et al., 1998)
      Comments

      The "RJ36" mutant and the "6356-001" mutant fail to complement each other, resulting in female sterility.

      (Tinker et al., 1998)
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer

      Associated with: solo6356-001.

      (Yan et al., 2010)
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (3)
      Reported As
      Symbol Synonym
      cgt6356-001
      fs(2)6356001
      (Tinker et al., 1998)
      vas6356-001
      (Yan et al., 2010)
      Name Synonyms
      Secondary FlyBase IDs
        References (2)