FlyBase Allele Report: Dmel\qm[L14.4]

General Information

Symbol

Dmel\qm^L14.4

Species

D. melanogaster

Name

FlyBase ID

FBal0091194

Feature type

allele

Associated gene

Dmel\qm

Associated Insertion(s)

Carried in Construct

Key Links

Genomic Maps

JBrowse

Allele class

Mutagen

ethyl methanesulfonate

Nature of the Allele

Allele class

Mutagen

ethyl methanesulfonate

(Lai et al., 1998)

Progenitor genotype

Cytology

Description

Amino acid replacement: K12term.

(Lai et al., 1998)

Nucleotide substitution: A34T.

(Lai et al., 1998)

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

point_mutation

3L:7,348,643..7,348,643 [+]

Nucleotide change:

A7348643T

Reported nucleotide change:

A34T

Amino acid change:

K12term | qm-PA; K12term | qm-PB; K12term | qm-PC

Reported amino acid change:

K12term

(Lai et al., 1998)

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

female sterile | germline clone

(Santos and Lehmann, 2004)

lethal (with Df(3L)BSC33)

(Cook, 2015.11.25)

lethal - all die before end of larval stage | recessive

(Lai et al., 1998)

some die during larval stage | recessive

(Lai et al., 1998)

Phenotype Manifest In

cardioblast

(Yi et al., 2006)

cephalopharyngeal skeleton

(Lai et al., 1998)

embryonic pericardial cell

(Yi et al., 2006)

larva

(Lai et al., 1998)

primordial germ cell

(Santos and Lehmann, 2004)

Detailed Description

Statement

Reference

Homozygous stage 17 embryos show a "broken hearted" phenotype; the pericardial cells are dissociated from cardioblasts in the dorsal vessel.

(Yi et al., 2006)

In embryos homozygous for qm^L14.4, a small number of germ cells (4 on average) fail to migrate into the mesoderm. Females in which the germ-line is homozygous for Hmgcr^clb1 are sterile.

(Santos and Lehmann, 2004)

Homozygotes and hemizygotes with Df(3L)Hn^DEB die as larvae 5 days after hatching. Their mouthparts remain as those of first instar larvae and they have a much reduced body size compared to wild-type larvae of the same age.

(Lai et al., 1998)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Phenotype Manifest In

Enhanced by

Statement

Reference

qm^L14.4 has primordial germ cell phenotype, enhanceable by Fpps^k06103

(Santos and Lehmann, 2004)

qm^L14.4 has primordial germ cell phenotype, enhanceable by Hmgcr⁰¹¹⁵²

(Santos and Lehmann, 2004)

Enhancer of

Statement

Reference

qm^L14.4 is an enhancer of primordial germ cell phenotype of Fpps^k06103

(Santos and Lehmann, 2004)

qm^L14.4 is an enhancer of primordial germ cell phenotype of Hmgcr⁰¹¹⁵²

(Santos and Lehmann, 2004)

Suppressor of

Statement

Reference

qm^L14.4/qm[+] is a suppressor of primordial germ cell | maternal effect | embryonic stage 5 phenotype of Neurl4^Δ1

(Jones and Macdonald, 2015)

Additional Comments

Genetic Interactions

Statement

Reference

The defective germ cell migration phenotype of qm^L14.4 homomzygous embryos is significantly enhanced by Fpps^k06103/Fpps^k06103 or Hmgcr⁰¹¹⁵²/Hmgcr⁰¹¹⁵².

(Santos and Lehmann, 2004)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Fails to complement

qm^15.1

(Lai et al., 1998)

qm²

(Lai et al., 1998)

Rescued by

qm^L14.4 is rescued by qm^+t11.5