FB2024_03 , released June 25, 2024
Allele: Dmel\okrAB
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General Information
Symbol
Dmel\okrAB
Species
D. melanogaster
Name
FlyBase ID
FBal0092591
Feature type
allele
Associated gene
Dmel\okr
Associated Insertion(s)
Carried in Construct
Key Links
Genomic Maps

Allele class

antimorphic allele - genetic evidence

Mutagen
Nature of the Allele
Allele class

antimorphic allele - genetic evidence

(Ghabrial et al., 1998)
Mutagen
ethyl methanesulfonate
(Ghabrial et al., 1998)
Progenitor genotype
Cytology
Description

Amino acid replacement: S325F.

(Ghabrial et al., 1998)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
point_mutation
2L:2,991,679..2,991,679 [-]
Nucleotide change:

C2991679T

Amino acid change:

S325F | okr-PA

Comment:

Site of nucleotide substitution in mutant inferred by FlyBase based on reported amino acid change.

(Ghabrial et al., 1998)
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Homozygous and hemizygous okrAB/Df(2L)JS17 females produce eggs with a range of eggshell phenotypes; from resembling wild-type with two normal dorsal appendages, having two dorsal appendages fused at the base, having a single dorsal appendage to having little or no dorsal appendage material. In up to 42% of eggs laid by hemizygous females a second micropyle is observed at the posterior pole of the egg, indicating that the follicle cells have adopted an anterior fate. Hemizygotes are viable.

      (Ghabrial et al., 1998)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Fails to complement

      okrWS

      (Ghabrial et al., 1998)
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (1)
      Reported As
      Symbol Synonym
      okrAB
      Name Synonyms
      Secondary FlyBase IDs
        References (1)