FB2024_03 , released June 25, 2024
Allele: Dmel\drlunspecified
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General Information
Symbol
Dmel\drlunspecified
Species
D. melanogaster
Name
FlyBase ID
FBal0093075
Feature type
allele
Associated gene
Dmel\drl
Associated Insertion(s)
Carried in Construct
Key Links
Allele class
Mutagen
    Nature of the Allele
    Allele class
    Mutagen
    Progenitor genotype
    Cytology
    Description
    Mutations Mapped to the Genome
    Curation Data
    Type
    Location
    Additional Notes
    References
    Variant Molecular Consequences
    Associated Sequence Data
    DDBJ / EMBL / GenBank
    DNA sequence
    Protein sequence
     
    UniProtKB/Swiss-Prot
      UniProtKB/TrEMBL
        Expression Data
        Reporter Expression
        Additional Information
        Statement
        Reference
         
        Marker for
        Reflects expression of
        Reporter construct used in assay
        Human Disease Associations
        Disease Ontology (DO) Annotations
        Models Based on Experimental Evidence ( 0 )
        Disease
        Evidence
        References
        Modifiers Based on Experimental Evidence ( 0 )
        Disease
        Interaction
        References
        Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
         
        Disease-implicated variant(s)
         
        Phenotypic Data
        Phenotypic Class
        Phenotype Manifest In
        Detailed Description
        Statement
        Reference

        The dendritic patterns of the adPN, lPN and vPN projection neurons are severely disrupted in homozygous adults. In some cases the dendrites are seen to project to the contralateral antennal lobe and subesophageal ganglion. DL1 dendrites arborise correctly in the dorsal antennal lobe, but they also frequently extend a branch to the ventromedial antennal lobe. The mutant phenotypes mostly become apparent between 24 and 26 hours after puparium formation.

        Clones of homozygous adPN, lPN, vPDN or DL1 PN projection neurons in a heterozygous background show severely disrupted dendritic targeting. Homozygous adPNs fail to target VA3, and mis-target to DM5, VM1 and V. Homozygous lPNs fail to target their normal DA2 regions and instead mistarget to VM6, VL1 and V. The position of DA1 is shifted ventrally. Homozygous vPNs fail to target VA1lm and DA1 and can project dendrites into the subesophageal ganglion. Homozygous DL1 dendrites mistarget to the ventral part of the antennal lobe.

        (Wu et al., 2014)

        In contrast to the abnormal behaviour of anterior commissure axons, posterior commissure axons do not appear to cross into the anterior commissure in mutant embryos.

        (Bonkowsky et al., 1999)
        External Data
        Interactions
        Show genetic interaction network for Enhancers & Suppressors
        Phenotypic Class
        Enhanced by
        Statement
        Reference

        drlunspecified has abnormal neuroanatomy | adult stage phenotype, enhanceable by Wnt5[+]/Wnt5unspecified

        (Wu et al., 2014)
        Suppressed by
        Statement
        Reference

        drlunspecified has abnormal neuroanatomy | adult stage phenotype, suppressible by Wnt5[+]/Wnt5unspecified

        (Wu et al., 2014)
        Phenotype Manifest In
        Additional Comments
        Genetic Interactions
        Statement
        Reference

        Wnt5unspecified/+ largely suppresses the dendritic targeting defects of homozygous drlunspecified adPN, lPN and vPN projection neuron clones, while the penetrance of the DL1 mistargeting phenotype is slightly increased.

        (Wu et al., 2014)

        The posterior commissure to anterior commissure switching activity is strongly suppressed by Df(1)N19.

        (Yoshikawa et al., 2003)
        Xenogenetic Interactions
        Statement
        Reference
        Complementation and Rescue Data
        Partially rescued by

        drlunspecified is partially rescued by drltMa

        (Simon et al., 1998)
        Comments

        Expression of drlScer\UAS.cYa in homozygous drlunspecified MARCM projection neuron clones induced in a drlunspecified/+ background substantially rescues the dendrite targeting defects of these clones, although some gain of function phenotypes are also seen.

        Expression of drlΔintra.Scer\UAS.T:Hsap\MYC in homozygous drlunspecified MARCM projection neuron clones induced in a drlunspecified/+ background fails to rescue the dendrite targeting defects of these clones.

        (Wu et al., 2014)
        Images (0)
        Mutant
        Wild-type
        Stocks (0)
        Notes on Origin
        Discoverer
        External Crossreferences and Linkouts ( 0 )
        Synonyms and Secondary IDs (1)
        Reported As
        Symbol Synonym
        drlunspecified
        Name Synonyms
        Secondary FlyBase IDs
          References (4)