FlyBase Allele Report: Dmel\sktl[UAS.cHa]

General Information

Symbol

Dmel\sktl^UAS.cHa

Species

D. melanogaster

Name

FlyBase ID

FBal0094337

Feature type

allele

Associated gene

Dmel\sktl

Associated Insertion(s)

Carried in Construct

P{UAS-sktl.H}

Also Known As

UAS-sktl

Key Links

Transgenic product class

cDNA

(Hassan et al., 1998)

wild_type

(Hassan et al., 1998)

Mutagen

in vitro construct

Nature of the Allele

Transgenic product class

cDNA

(Hassan et al., 1998)

wild_type

(Hassan et al., 1998)

Mutagen

in vitro construct

(Hassan et al., 1998)

Progenitor genotype

Carried in construct

P{UAS-sktl.H}

Cytology

Description

Expression of a sktl cDNA is governed by UASt regulatory sequences.

(Hassan et al., 1998)

Allele components

Component

Use(s)

Regulatory region(s)

UASt

binary expression system - regulatory region

Encoded product / tool

sktl

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

Phenotype Manifest In

axon | adult stage, with Scer\GAL4^pnr-MD237

(Urwyler et al., 2019)

macrochaeta, with Scer\GAL4^32B

(Hassan et al., 1998)

macrochaeta | ectopic, with Scer\GAL4^32B

(Hassan et al., 1998)

macrochaeta | ectopic, with Scer\GAL4^dpp.blk1

(Hassan et al., 1998)

mechanosensory neuron | adult stage, with Scer\GAL4^pnr-MD237

(Urwyler et al., 2019)

neuron projection | adult stage | ectopic, with Scer\GAL4^pnr-MD237

(Urwyler et al., 2019)

scutum, with Scer\GAL4^32B

(Hassan et al., 1998)

scutum, with Scer\GAL4^dpp.blk1

(Hassan et al., 1998)

scutum & macrochaeta, with Scer\GAL4^32B

(Hassan et al., 1998)

scutum & macrochaeta, with Scer\GAL4^dpp.blk1

(Hassan et al., 1998)

wing, with Scer\GAL4^32B

(Hassan et al., 1998)

wing, with Scer\GAL4^dpp.blk1

(Hassan et al., 1998)

wing & macrochaeta, with Scer\GAL4^32B

(Hassan et al., 1998)

wing & macrochaeta, with Scer\GAL4^dpp.blk1

(Hassan et al., 1998)

Detailed Description

Statement

Reference

Posterior dorsocentral bristle neurons expressing sktl^UAS.cHa under the control of Scer\GAL4^pnr-MD237 show a significantly decreased terminal arbor territory, as compared to controls.

(Urwyler et al., 2019)

When expression is driven by an elav-Scer\GAL4, no phenotype results. When expression is driven by Scer\GAL4^da.G32 or a heat shock Scer\GAL4, no phenotype results but early larval lethality results. When expression is driven by Scer\GAL4^T80 third instar larval lethality results. Expression driven by Scer\GAL4^dpp.blk1 causes no eye phenotype but ectopic bristles on the notum and wing blade. When expression is driven by Scer\GAL4^32B ectopic bristles appear on the notum and wing blade. The ectopic bristles as well as the normal bristles show structural defects consistent with a role for sktl in the cytoskeleton. All ectopic bristles are associated with socket cells.