FB2024_03 , released June 25, 2024
Allele: Dmel\Su(z)124
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General Information
Symbol
Dmel\Su(z)124
Species
D. melanogaster
Name
FlyBase ID
FBal0094493
Feature type
allele
Associated gene
Dmel\Su(z)12
Associated Insertion(s)
Carried in Construct
Key Links
Genomic Maps

Allele class
Mutagen
Nature of the Allele
Allele class
Mutagen
ethyl methanesulfonate
(Kehle et al., 1998)
Progenitor genotype
Cytology
Description

Amino acid replacement: Q219term.

(Birve et al., 2001)

Nucleotide substitution: C?T.

(Birve et al., 2001)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
point_mutation
3L:19,922,039..19,922,039 [-]
Nucleotide change:

C19922039T

Reported nucleotide change:

C?T

Amino acid change:

Q219term | Su(z)12-PA; Q219term | Su(z)12-PB

Reported amino acid change:

Q219term

(Birve et al., 2001)
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In

      dendrite & dorsal multidendritic neuron ddaC | somatic clone

      (Parrish et al., 2007)

      ovary | germline clone

      (Iovino et al., 2013)
      Detailed Description
      Statement
      Reference

      Homozygous germline clones result in degeneration of the ovary prior to vitellogenic stages.

      (Iovino et al., 2013)

      Single cell class IV dendrite arborisation (da) neuron clones that are homozygous for Su(z)124 show a range of dendritic defects in the third instar larva. Homozygous class IV ddaC clones show a significant reduction in dendrite branching and total dendritic length compared to controls.

      Heterozygous larvae show no significant defects in dendrite morphology of class IV dendrite arborisation (da) neurons.

      (Parrish et al., 2007)

      Eggs are not recovered from females carrying homozygous germ-line clones.

      (Birve et al., 2001)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Suppressor of
      Statement
      Reference

      Su(z)124 is a suppressor of visible phenotype of Scer\GAL4lz-gal4, sensUAS.cNa

      (Anderson et al., 2011)
      Other
      Phenotype Manifest In
      Suppressor of
      Statement
      Reference

      Su(z)124 is a suppressor of eye phenotype of Scer\GAL4lz-gal4, sensUAS.cNa

      (Anderson et al., 2011)
      Other
      Statement
      Reference

      E(z)63, Su(z)124/Su(z)12[+] has dendrite & dorsal multidendritic neuron ddaC phenotype

      (Parrish et al., 2007)
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      The disorganised eye phenotype caused by expression of sensScer\UAS.cNa under the control of Scer\GAL4lz-gal4 is suppressed by Su(z)124.

      (Anderson et al., 2011)

      Pc1/Su(z)124 double heterozygous larvae show dendritic defects in class IV dendrite arborisation (da) neurons; there is a significant reduction in the number of dendritic branchpoints.

      (Parrish et al., 2007)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Fails to complement

      Su(z)121

      (Birve et al., 2001)
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (1)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (3)
      References (16)