FB2024_03 , released June 25, 2024
Allele: Dmel\locoM1
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General Information
Symbol
Dmel\locoM1
Species
D. melanogaster
Name
FlyBase ID
FBal0096752
Feature type
allele
Associated gene
Dmel\loco
Associated Insertion(s)
Carried in Construct
Key Links
Allele class

loss of function allele

Mutagen
Nature of the Allele
Allele class

loss of function allele

(Granderath et al., 1999)
Mutagen
ethyl methanesulfonate
(Granderath et al., 1999)
Progenitor genotype
Cytology
Description
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Heterozygotes of locoA1/locoM1 escape as viable adults with behavioural defects. Heterozygotes of locoL1/locoM1 occasionally survive as viable adults at 18oC but are pupal lethal at 25oC. Heterozygotes of locoF1/locoM1 occasionally survive as eclosing adults at 18oC but are pupal lethal at 25oC. When trans with locoΔ13 or locoΔ293 at 25oC escapers are produced. Escapers show a paralytic phenotype, and drop into the food and die of not rescued. Rescued adults show a severe impairment of spontaneous locomotor activity and show a shaking phenotype. Response to mechanical stimulation is weak (for locoΔ293) and non-existent (for locoΔ13). All adult escapers die after a maximum of 2 days.

      (Granderath et al., 1999)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      NOT Enhancer of
      NOT Suppressor of
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      No modification of the G-oα47AScer\UAS.cKa overexpression phenotype (under Scer\GAL4Bx-MS1096 control) is observed in locoM1 heterozygous mutants.

      (Katanaev and Tomlinson, 2006)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      Comments
      Comments

      Based on lethal phase (which ranges from larval lethal to viable) alleles can be placed in an allelic series, going from strongest to weakest: locoL1 > locoF1 > locoT1 = locoA1 > locoM1.

      (Granderath et al., 1999)
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (1)
      Reported As
      Symbol Synonym
      locoM1
      Name Synonyms
      Secondary FlyBase IDs
        References (2)