FlyBase Allele Report: Dmel\Nrg[G0099]

General Information

Symbol

Dmel\Nrg^G0099

Species

D. melanogaster

Name

FlyBase ID

FBal0098204

Feature type

allele

Associated gene

Dmel\Nrg

Associated Insertion(s)

P{lacW}Nrg^G0099

Carried in Construct

Key Links

Genomic Maps

JBrowse

Allele class

Mutagen

P-element activity

Nature of the Allele

Allele class

Mutagen

P-element activity

(Schäfer et al., 1999.6.15)

Progenitor genotype

Associated Insertion(s)

P{lacW}Nrg^G0099

Cytology

Description

Allele components

Component

Use(s)

Inserted element

P{lacW}

enhancer trap

Encoded product / tool

lacZ

reporter enzyme

Tagged with

Tag:NLS(P)

nuclear protein localization tag

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

transposable_element_insertion_site

X:8,517,519..8,517,617 [+]

(Peter et al., 2002, Schäfer et al., 1999.6.15)

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

AJ426788

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 1 )

Disease

Interaction

References

ameliorates tauopathy

modeled by Hsap\MAPT^GMR.Ex.PJ

(Ambegaokar and Jackson, 2011)

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal courtship behavior | female (with Nrg⁸⁴⁹)

(Carhan et al., 2005)

abnormal courtship behavior | female (with Nrg⁸⁹²)

(Carhan et al., 2005)

abnormal courtship behavior | female (with Nrg^ibx)

(Carhan et al., 2005)

lethal | adult stage

(Peter et al., 2002)

lethal | heat sensitive (with Nrg^l10)

(Carhan et al., 2005)

lethal | pharate adult stage

(Peter et al., 2002)

lethal | pupal stage

(Peter et al., 2002)

lethal | recessive

(Schäfer et al., 1999.6.15)

Phenotype Manifest In

Detailed Description

Statement

Reference

Nrg^G0099/Nrg^l10 flies are viable at 18[o]C and rare escapers are seen at 25[o]C.

Nrg^G0099/Nrg⁸⁴⁹ and Nrg^G0099/Nrg⁸⁹² females show reduced sexual receptivity compared to controls when mated to wild-type males.

(Carhan et al., 2005)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Suppressor of

Statement

Reference

Nrg[+]/Nrg^G0099 is a suppressor of visible phenotype of Hsap\MAPT^GMR.Ex.PJ

(Ambegaokar and Jackson, 2011)

NOT Suppressor of

Statement

Reference

Nrg[+]/Nrg^G0099 is a non-suppressor of visible phenotype of Scer\GAL4^GMR.PU, Zzzz\CAG^Q108.UAS

(Ambegaokar and Jackson, 2011)

Phenotype Manifest In

Suppressor of

Statement

Reference

Nrg[+]/Nrg^G0099 is a suppressor of eye phenotype of Hsap\MAPT^GMR.Ex.PJ

(Ambegaokar and Jackson, 2011)

NOT Suppressor of

Statement

Reference

Nrg[+]/Nrg^G0099 is a non-suppressor of eye phenotype of Scer\GAL4^GMR.PU, Zzzz\CAG^Q108.UAS

(Ambegaokar and Jackson, 2011)

Additional Comments

Genetic Interactions

Statement

Reference

One copy of Nrg^G0099 does not suppress the apoptosis seen in flies overexpressing hid.

(Ambegaokar and Jackson, 2011)

Xenogenetic Interactions

Statement

Reference

One copy of Nrg^G0099 suppresses the rough eye phenotype seen in flies expressing Hsap\MAPT^GMR.Ex.PJ.

One copy of Nrg^G0099 does not suppress the rough eye phenotype seen in flies expressing Zzzz\CAG^{Q108.Scer\UAS} under the control of Scer\GAL4^GMR.PU.

(Ambegaokar and Jackson, 2011)

Complementation and Rescue Data

Fails to complement

Nrg^ibx

(Carhan et al., 2005)

Nrg^l10

(Carhan et al., 2005)

Nrg⁸⁹²

(Carhan et al., 2005)

Comments

Nrg^G0099 fails to complement the reduced female receptivity phenotype of Nrg^ibx and of Nrg⁸⁹².

(Carhan et al., 2005)

Images (0)

Mutant

Wild-type

Stocks (2)

Bloomington

11814

w^67c23 P{lacW}Nrg^G0099/FM7c

Kyoto

111783

w^67c23 P{lacW}Nrg^G0099 P{neoFRT}19A/FM7c; P{ey-FLP.N}5

Notes on Origin

Discoverer

Comments

P{lacW} not verified as causing the lethality.

(Schäfer et al., 1999.6.15)

External Crossreferences and Linkouts ( 1 )

Crossreferences

GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.

AJ426788

Synonyms and Secondary IDs (3)

Reported As

Symbol Synonym

Nrg^G0099

(Ambegaokar and Jackson, 2011, Mao and Freeman, 2009)

l(1)G0099

(Carhan et al., 2005, Peter et al., 2002)

l(1)G0099^G0099

(Schäfer et al., 1999.6.15)

Name Synonyms

Secondary FlyBase IDs

References (5)

Report Sections

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