FlyBase Allele Report: Dmel\hep[CA]

General Information

Symbol

Dmel\hep^CA

Species

D. melanogaster

Name

FlyBase ID

FBal0098235

Feature type

allele

Associated gene

Dmel\hep

Associated Insertion(s)

P{UAS-hep.CA}CA

Carried in Construct

Key Links

Allele class

Mutagen

P-element activity

Nature of the Allele

Allele class

Mutagen

P-element activity

(Adachi-Yamada et al., 1999)

Progenitor genotype

hep^CA.UAS

(Adachi-Yamada et al., 1999)

Associated Insertion(s)

P{UAS-hep.CA}CA

Cytology

Description

Expression is presumed to be due to a genomic enhancer driving expression of the P{UAS-hep.CA} transgene.

(Adachi-Yamada et al., 1999)

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

increased cell death

(Miotto et al., 2006)

increased cell death | heat sensitive, with Scer\GAL4^en-e16E, Scer\GAL80^ts.αTub84B

(Ryoo et al., 2004)

visible | dominant

(Miotto et al., 2006, Chen et al., 2002, Adachi-Yamada et al., 1999)

Phenotype Manifest In

wing

(Miotto et al., 2006, Chen et al., 2002, Adachi-Yamada et al., 1999)

wing disc

(Adachi-Yamada et al., 1999)

Detailed Description

Statement

Reference

Heterozygotes have wing notches of variable extent.

(Miotto et al., 2006)

Shifting hep^CA; Scer\GAL4^en-e16E; Scer\GAL80^ts.αTub84B flies to the none permissive temperature for Scer\GAL80^ts.αTub84B induces expression of cell death markers in the posterior compartment of the wing disc by 22 hours after the shift.

(Ryoo et al., 2004)

10% of heterozygous flies lack part of the wing.

(Chen et al., 2002)

hep^CA heterozygotes show notching of the wing in less than 10% of cases. Massive cell death is seen in both the proximal and distal wing primordia in the hep^CA late third larval instar wing disc.

(Adachi-Yamada et al., 1999)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Enhanced by

Statement

Reference

hep^CA has visible | dominant phenotype, enhanceable by HDAC1⁰⁴⁵⁵⁶/Rpd3[+]

(Miotto et al., 2006)

Suppressed by

Statement

Reference

hep^CA has increased cell death phenotype, suppressible by chm¹⁴/chm[+]

(Miotto et al., 2006)

hep^CA has visible | dominant phenotype, suppressible by chm¹⁴/chm[+]

(Miotto et al., 2006)

hep^CA has visible | dominant phenotype, suppressible by kay¹/kay[+]

(Miotto et al., 2006)

hep^CA has visible | dominant phenotype, suppressible by Jra^IA109/Jra[+]

(Miotto et al., 2006)

hep^CA has visible | dominant phenotype, suppressible by Cka²/Cka[+]

(Chen et al., 2002)

Enhancer of

Statement

Reference

hep[+]/hep^CA is an enhancer of visible phenotype of dpp^hr56/dpp^d8

(Adachi-Yamada et al., 1999)

hep^CA is an enhancer of visible phenotype of tkv⁷/tkv⁴²⁷

(Adachi-Yamada et al., 1999)

hep[+]/hep^CA is an enhancer of visible | recessive phenotype of bi^omb-1

(Adachi-Yamada et al., 1999)

Phenotype Manifest In

Enhanced by

Statement

Reference

hep^CA has wing phenotype, enhanceable by HDAC1⁰⁴⁵⁵⁶/Rpd3[+]

(Miotto et al., 2006)

Suppressed by

Statement

Reference

hep^CA has wing phenotype, suppressible by Jra^IA109/Jra[+]

(Miotto et al., 2006)

hep^CA has wing phenotype, suppressible by chm¹⁴/chm[+]

(Miotto et al., 2006)

hep^CA has wing phenotype, suppressible by kay¹/kay[+]

(Miotto et al., 2006)

hep^CA has wing phenotype, suppressible by Cka²/Cka[+]

(Chen et al., 2002)

Enhancer of

Statement

Reference

hep[+]/hep^CA is an enhancer of wing phenotype of dpp^hr56/dpp^d8

(Adachi-Yamada et al., 1999)

hep^CA is an enhancer of wing phenotype of tkv⁷/tkv⁴²⁷

(Adachi-Yamada et al., 1999)

hep[+]/hep^CA is an enhancer of wing phenotype of bi^omb-1

(Adachi-Yamada et al., 1999)

Additional Comments

Genetic Interactions

Statement

Reference

The loss of wing tissue seen in some hep^CA/+ flies is rescued by Cka²/+.

(Chen et al., 2002)

Dominantly enhances the wing notching phenotype of dpp^d8/dpp^hr56, tkv⁷/tkv⁴²⁷ or bi^omb-1/Y flies; a wide region of the wing blade is lost, leaving only the base of the wing.

(Adachi-Yamada et al., 1999)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (3)

Reported As

Symbol Synonym

hep<up>CA(wing trap)</up>

(Adachi-Yamada et al., 1999)

hep^CA20

(Ryoo et al., 2004)

hep^CA

Name Synonyms

Secondary FlyBase IDs

References (5)

Report Sections

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