FB2024_03 , released June 25, 2024
Allele: Dmel\larkZF.Tag:HA
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General Information
Symbol
Dmel\larkZF.Tag:HA
Species
D. melanogaster
Name
FlyBase ID
FBal0103669
Feature type
allele
Associated gene
Dmel\lark
Associated Insertion(s)
Carried in Construct
P{lark.ZF}
Key Links
Transgenic product class
missense_variant
(McNeil et al., 1999)
Mutagen
Nature of the Allele
Transgenic product class
missense_variant
(McNeil et al., 1999)
Mutagen
in vitro construct
(McNeil et al., 1999)
Progenitor genotype
lark+mMa
(McNeil et al., 1999)
Carried in construct
P{lark.ZF}
Cytology
Description

A mutated lark transgene in which the first two cysteines within the zinc finger domain are mutated to tyrosines is tagged with Tag:HA.

(McNeil et al., 1999)
Allele components
Component
Use(s)
Regulatory region(s)
lark
Encoded product / tool
lark
Tagged with
Tag:HA
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      lark1 animals rescued by larkZF.T:Ivir\HA1 have scutellar bristle defects (such as a missing or malformed posterior scutellar bristle and ectopic bristles). The penetrance of the bristle phenotype is 66-99%. The flies also have a "held out" wing phenotype with 100% penetrance. lark1 homozygotes carrying larkZF.T:Ivir\HA1 show normal eclosion rhythms in 12 hour light:12 hour darkness conditions and normal free-running eclosion rhythms.

      (McNeil et al., 2001)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Partially rescues

      larkZF.Tag:HA partially rescues lark1

      (McNeil et al., 2001)

      larkZF.Tag:HA partially rescues lark1

      (McNeil et al., 1999)
      Comments

      Rescues the embryonic lethality phenotype of lark1 flies, but females develop to become sterile.

      (McNeil et al., 1999)
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      larkZF.T:Ivir\HA1
      larkZF.Tag:HA
      Name Synonyms
      Secondary FlyBase IDs
        References (2)