FlyBase Allele Report: Dmel\Pten[3]

General Information

Symbol

Dmel\Pten³

Species

D. melanogaster

Name

FlyBase ID

FBal0104063

Feature type

allele

Associated gene

Dmel\Pten

Associated Insertion(s)

Carried in Construct

Key Links

Allele class

Mutagen

ethyl methanesulfonate

Nature of the Allele

Allele class

Mutagen

ethyl methanesulfonate

(Goberdhan et al., 1999)

Progenitor genotype

Cytology

Description

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

flightless (with Pten⁵)

(Mensah et al., 2015)

hyperplasia | somatic clone

(Hietakangas and Cohen, 2007, Goberdhan et al., 1999)

lethal | recessive

(Goberdhan et al., 1999)

lethal - all die before end of larval stage (with Df(2L)flp170B)

(Vereshchagina et al., 2008)

some die during third instar larval stage (with Df(2L)flp170B)

(Vereshchagina et al., 2008)

Phenotype Manifest In

crossvein | somatic clone

(Goberdhan et al., 1999)

eye | somatic clone

(Hietakangas and Cohen, 2007, Goberdhan et al., 1999)

interommatidial bristle | somatic clone

(Goberdhan et al., 1999)

ommatidium | somatic clone

(Goberdhan et al., 1999)

photoreceptor neuron | cell autonomous | somatic clone

(Goberdhan et al., 1999)

rhabdomere | cell autonomous | somatic clone

(Goberdhan et al., 1999)

wing & cell | somatic clone

(Goberdhan et al., 1999)

wing | somatic clone

(Goberdhan et al., 1999)

wing hair | ectopic | somatic clone

(Goberdhan et al., 1999)

Detailed Description

Statement

Reference

Homozygous clones in the eye disc result in strong overgrowth of the eye.

(Hietakangas and Cohen, 2007)

Hemizygotes die as late embryos or early first instar larvae. Homozygous mutant clones in the eye bulge out from the eye surface. Ommatidia sometimes fuse interommatidial bristles are abnormal, particularly (but not exclusively) in the dorsal half of the eye. Mutant clones typically contain at least twice as many ommatidia as their wild type twin spots. The largest clones can form a hyperplastic tumor-like overgrowth, though this phenotype is less severe than for tumor suppressor mutations. Within each ommatidium cell type specification seems normal. Cell bodies of mutant photoreceptors are enlarged compared to wild type neighbors, and the rhabdomeres are misshapen. The cell size and rhabdomeric phenotypes are cell autonomous. Homozygous mutant clones in the wing reveal an increase in cell size. Wing hairs are occasionally duplicated and crossvein formation is abnormal. Occasional extra wing vein material develops. Longitudinal veins are rarely affected.

(Goberdhan et al., 1999)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Suppressed by

Statement

Reference

Pten³/Pten⁵ has flightless phenotype, suppressible | partially by Akt1[+]/Akt¹

(Mensah et al., 2015)

Df(2L)flp170B/Pten³ has lethal | late third instar larval stage phenotype, suppressible | partially by Akt1[+]/Akt¹

(Vereshchagina et al., 2008)

Df(2L)flp170B/Pten³ has lethal | late third instar larval stage phenotype, suppressible | partially by gig^UAS.cTa/Scer\GAL4^arm.PS/Tsc1^UAS.cGa

(Vereshchagina et al., 2008)

Df(2L)flp170B/Pten³ has lethal | late third instar larval stage phenotype, suppressible | partially by wdb^GS9548/Scer\GAL4^arm.PS

(Vereshchagina et al., 2008)

Pten³ has hyperplasia | somatic clone phenotype, suppressible by rictor^Δ2

(Hietakangas and Cohen, 2007)

Phenotype Manifest In

Suppressed by

Statement

Reference

Pten³ has eye | somatic clone phenotype, suppressible by rictor^Δ2

(Hietakangas and Cohen, 2007)

Additional Comments

Genetic Interactions

Statement

Reference

77% of Pten³/Df(2L)flp170B animals survive to adulthood in the presence of Akt1¹/+.

Expression of Tsc1^Scer\UAS.cGa and gig^Scer\UAS.cGa under the control of Scer\GAL4^arm.PS rescues lethality in 40% of Pten³/Df(2L)flp170B animals.

Expression of wdb^GS9548 under the control of Scer\GAL4^arm.PS rescues lethality in 52% of Pten³/Df(2L)flp170B animals.

(Vereshchagina et al., 2008)

rictor^Δ2 suppresses the overgrowth of the eye caused by homozygous Pten³ clones.

(Hietakangas and Cohen, 2007)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Fails to complement

Pten¹

(Goberdhan et al., 1999)

Rescued by

Pten³ is rescued by Pten^+t6.3

(Goberdhan et al., 1999)

Pten³ is rescued by Pten^hs.PG

(Goberdhan et al., 1999)

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (4)

Reported As

Symbol Synonym

DPTEN³

(Goberdhan et al., 1999)

PTEN³

(Kim et al., 2017, Vereshchagina et al., 2008, Hietakangas and Cohen, 2007, Pinal et al., 2006)

Pten³

(Mensah et al., 2015, Lee et al., 2010)

pten³

(Murray et al., 2012)

Name Synonyms

Secondary FlyBase IDs

References (9)

Report Sections

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