FB2024_03 , released June 25, 2024
Allele: Dmel\alcAd2
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General Information
Symbol
Dmel\alcAd2
Species
D. melanogaster
Name
FlyBase ID
FBal0104541
Feature type
allele
Associated gene
Dmel\alc
Associated Insertion(s)
Carried in Construct
Key Links
Genomic Maps

Allele class
Mutagen
Nature of the Allele
Allele class
Mutagen
ethyl methanesulfonate
(Dockendorff et al., 2000)
Progenitor genotype
Cytology
Description

Nonsense point mutation introduces a stop codon at R233 of the RA (long) transcript. This is equivalent to R112 of the RB (short) transcript)

(Spasić et al., 2008)

Amino acid replacement: R233term.

(Spasić et al., 2008)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
point_mutation
2R:9,135,947..9,135,947 [-]
Nucleotide change:

C9135947T

Amino acid change:

R233term | alc-PA; R112term | alc-PB

Reported amino acid change:

R233term

Comment:

Site of nucleotide substitution in mutant inferred by FlyBase based on reported amino acid change.

(Spasić et al., 2008)
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      The range of stages during which lethality of alcAd2 homozygotes, alcAd2/alcΔ12.125 or alcΔ12.125/Df(2R)Np5 occurs is similar, ranging from first instar larvae to pupal stages.

      Adults with alcAd2 homozygous eyes and antennae (inducing homozygous somatic clones in the eye and antenna with Scer\GAL4ey.PH; Scer\FLP1Scer\UAS.cDa and killing non-mutant cells in the eye with WGMR.PG) show progressive neuro-degeneration in the antenna, retina and optic lobes, characterized by the death of neurons and the formation of vacuoles.

      Retinal development in alcAd2 homozygous clones during pupal stages appears to be normal - photoreceptors are specified and patterned correctly and apical-basal polarity of cells in the developing retina is normal. Normal development in these clones is unaffected by starvation of larvae prior to pupation. However, when these clones are made in the follicle epithelia of starved adults, they do cause defects in apical-basal of the epithelium.

      (Spasić et al., 2008)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Images (0)
      Mutant
      Wild-type
      Stocks (2)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      alcAd2
      (Deichsel et al., 2024, Spasić et al., 2008)
      l(2)45Ad2
      (Spasić et al., 2008)
      Name Synonyms
      Secondary FlyBase IDs
        References (3)