FlyBase Allele Report: Dmel\ey[J5.71]

General Information

Symbol

Dmel\ey^J5.71

Species

D. melanogaster

Name

FlyBase ID

FBal0104630

Feature type

allele

Associated gene

Dmel\ey

Associated Insertion(s)

Carried in Construct

Key Links

Allele class

loss of function allele

Mutagen

ethyl methanesulfonate

Nature of the Allele

Allele class

loss of function allele

(Punzo et al., 2002, Kammermeier et al., 2001, Punzo et al., 2001)

Mutagen

ethyl methanesulfonate

(Kammermeier et al., 2001, Punzo et al., 2001)

Progenitor genotype

Cytology

Description

Mutation is due to a 9kb deletion in the 5' region of the ey gene.

(Punzo et al., 2001)

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal neuroanatomy (with ey^D1Da)

(Callaerts et al., 2001)

abnormal neuroanatomy (with ey^JD)

(Callaerts et al., 2001)

lethal - all die before end of pupal stage

(Jacobsson et al., 2009)

partially lethal (with ey^JD)

(Callaerts et al., 2001)

partially lethal | recessive

(Callaerts et al., 2001)

some die during pupal stage

(Jacobsson et al., 2009)

viable (with ey^D1Da)

(Callaerts et al., 2001)

visible

(Callaerts et al., 2001)

visible (with ey^D1Da)

(Callaerts et al., 2001)

visible (with ey^JD)

(Callaerts et al., 2001)

Phenotype Manifest In

adult central complex (with ey^D1Da)

(Callaerts et al., 2001)

adult central complex (with ey^JD)

(Callaerts et al., 2001)

adult mushroom body (with ey^D1Da)

(Callaerts et al., 2001)

adult mushroom body (with ey^JD)

(Callaerts et al., 2001)

eye

(Jacobsson et al., 2009, Punzo et al., 2002, Callaerts et al., 2001)

eye (with ey^D1Da)

(Callaerts et al., 2001)

eye (with ey^JD)

(Callaerts et al., 2001)

eye | ectopic, with Scer\GAL4^dpp.blk1, ey^ΔHD.UAS

(Punzo et al., 2001)

Detailed Description

Statement

Reference

Homozygous ey^J5.71 mutant escaper adults are not headless.

(Jacobsson et al., 2009)

20% of mutant flies show a 50-75% reduction in the size of the eye, and 80% of mutant flies show a 75-100% reduction in the size of the eye.

(Punzo et al., 2002)

Homozygotes show 81% lethality. Eyes are reduced in size in homozygotes; 80% have eyes that are 0-25% of wild-type size and 20% have eyes that are 25-50% of wild-type size. ey^JD/ey^J5.71 flies show 72% lethality. Eyes are reduced in size in ey^JD/ey^J5.71 flies; 22% have eyes that are 0-25% of wild-type size, 72% have eyes that are 25-50% of wild-type size, 6% have eyes that are 50-75% of wild-type size and 0% have eyes that are 75-100% of wild-type size. ey^JD/ey^J5.71 flies show severe mushroom body and central complex defects. Eyes are reduced in size in ey^D1Da/ey^J5.71 flies; 43% have eyes that are 0-25% of wild-type size, 14% have eyes that are 25-50% of wild-type size, 38% have eyes that are 50-75% of wild-type size and 5% have eyes that are 75-100% of wild-type size. ey^D1Da/ey^J5.71 flies show severe mushroom body and central complex defects.

(Callaerts et al., 2001)

No defects are seen in the embryonic central nervous system.

(Kammermeier et al., 2001)

Expression of ey^{Scer\UAS.ΔHD} when driven by Scer\GAL4^dpp.blk1 in a ey^J5.71 background leads to ectopic eyes.

(Punzo et al., 2001)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Suppressed by

Statement

Reference

ey^J5.71 has lethal | pupal stage phenotype, suppressible by toy^UAS.cCa/Scer\GAL4^toy1

(Jacobsson et al., 2009)

Phenotype Manifest In

Suppressed by

Statement

Reference

ey^J5.71 has eye phenotype, suppressible by toy^UAS.cCa/Scer\GAL4^toy1

(Jacobsson et al., 2009)

ey^J5.71 has eye phenotype, suppressible by toy^UAS.cCa/Scer\GAL4^ey.PH

(Punzo et al., 2002)

NOT Suppressor of

Statement

Reference

Scer\GAL4^dpp.blk1, ey^J5.71/ey^J5.71 is a non-suppressor of eye | ectopic phenotype of toy^ΔHD.UAS

(Punzo et al., 2004)

Scer\GAL4^dpp.blk1, ey^J5.71/ey^J5.71 is a non-suppressor of eye | ectopic phenotype of Mmus\Pax6^UAS.cHa

(Punzo et al., 2004)

Scer\GAL4^dpp.blk1, ey^J5.71/ey^J5.71 is a non-suppressor of eye | ectopic phenotype of toy^UAS.cCa

(Punzo et al., 2004)

Additional Comments

Genetic Interactions

Statement

Reference

Expression of toy^Scer\UAS.cCa under the control of Scer\GAL4^toy1 significantly suppresses the lethality seen in ey^J5.71 mutants, raising the fraction of homozygous adults from 12% to 26.8% at 18[o]C. The compound eyes of ey^J5.71 homozygotes are fully restored by one copy of toy^Scer\UAS.cCa.

(Jacobsson et al., 2009)

The ectopic eyes seen in flies in which Scer\GAL4^dpp.blk1 drives expression from toy^Scer\UAS.cCa, toy^{ΔHD.Scer\UAS} or Mmus\Pax6^Scer\UAS.cHa are not suppressed by ey^J5.71/ey^J5.71.

(Punzo et al., 2004)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Rescued by

ey^J5.71 is rescued by ey^UAS.cHa/Scer\GAL4^ey.PH

(Punzo et al., 2002)

ey^J5.71 is rescued by ey^ΔHD.UAS/Scer\GAL4^ey.PH

(Punzo et al., 2001)

Partially rescued by

ey^J5.71 is partially rescued by ey^+t.p6

(Punzo et al., 2004)

Not rescued by

ey^J5.71 is not rescued by ey^t.p14

(Punzo et al., 2004)

Comments

Embryonic and pupal lethality developmental delay, eye phenotypes and male sterility due to ey^J5.71/ey^J5.71 are all rescued by ey^+t.p6. However, female sterility is not. When somatic clones lacking ey^+t.p6 are induced in the late second or early third instar, eyes carrying these clones appear normal.

(Punzo et al., 2004)

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (2)

Reported As

Symbol Synonym

ey^J5.71

(Baker et al., 2018, Bertet et al., 2014, Li et al., 2013, Furukubo-Tokunaga et al., 2009, Jacobsson et al., 2009, Kurusu et al., 2009, Clements et al., 2008, Von Ohlen et al., 2007, Punzo et al., 2004)

ey^j5.71

(Konstantinides et al., 2022)

Name Synonyms

Secondary FlyBase IDs

References (16)

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