Amino acid replacement: W54term.
Mutation is predicted to result in a protein truncated in the first Ig domain (before the catalytic domain).
Nucleotide substitution: G?A.
G12736121A
G?A
W54term | Ptp69D-PA; W54term | Ptp69D-PB
W54term
G to A nucleotide change at the second or third position of the Trp codon leads to a nonsense mutation (exact site of mutation unspecified).
photoreceptor cell & axon | somatic clone
photoreceptor cell R7 & axon | somatic clone
At 25oC, the survival rates of homozygotes are: adult survival - 0%, eclosion - 5%, pupation 26%.
Mutant R7 axons show targeting defects.
Photoreceptor fates are correctly specified, but their axons project abnormally into the optic lobes in homozygous clones in the eye.
Ptp69DD1689 has photoreceptor cell R7 & axon | somatic clone phenotype, suppressible by Lar::Ptp69DLP.GMR.Tag:SS(wg),Tag:HA
Ptp69DD1689 has photoreceptor cell R7 & axon | somatic clone phenotype, suppressible by Lar::Ptp69DPL.GMR.Tag:SS(wg),Tag:HA
Ptp69DD1689 has photoreceptor cell R7 & axon | somatic clone phenotype, suppressible by LarGMR.Tag:SS(wg),Tag:HA
The targeting defects of Ptp69DD1689 R7 axons are rescued by LarGMR.T:wg,T:Ivir\HA1, Lar::Ptp69DLP.GMR.T:wg,T:Ivir\HA1 or Lar::Ptp69DPL.GMR.T:wg,T:Ivir\HA1.