FlyBase Allele Report: Dmel\cln[SF3-2]

General Information

Symbol

Dmel\cln^SF3-2

Species

D. melanogaster

Name

FlyBase ID

FBal0105039

Feature type

allele

Associated gene

cln

Associated Insertion(s)

Carried in Construct

Key Links

Allele class

amorphic allele - genetic evidence

Mutagen

ethyl methanesulfonate

Nature of the Allele

Allele class

amorphic allele - genetic evidence

(Taguchi et al., 2000)

Mutagen

ethyl methanesulfonate

(Taguchi et al., 2000)

Progenitor genotype

Cytology

Description

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal eye color | recessive

(Taguchi et al., 2000)

fertile

(Taguchi et al., 2000)

viable

(Taguchi et al., 2000)

visible | recessive

(Taguchi et al., 2000)

Phenotype Manifest In

cone cell

(Taguchi et al., 2000)

eye

(Taguchi et al., 2000)

eye disc & photoreceptor cell

(Taguchi et al., 2000)

ommatidium

(Taguchi et al., 2000)

photoreceptor neuron

(Taguchi et al., 2000)

pigment cell

(Taguchi et al., 2000)

secondary pigment cell | ectopic

(Taguchi et al., 2000)

tertiary pigment cell | ectopic

(Taguchi et al., 2000)

Detailed Description

Statement

Reference

Homozygotes have extremely rough eyes showing a characteristic "white and red" appearance due to a loss of pigments. The normal structure of the ommatidia is disrupted almost completely. The number of secondary and tertiary pigment cells is increased. Cone cells are deformed and their number and arrangement in the ommatidia is irregular. Homozygotes have normal wing vein patterns, and appear morphologically normal apart from the eye defects. Posterior to the morphogenetic furrow in the eye imaginal disc, relatively normal five-cell ommatidial preclusters form in homozygotes. However, the adjacent region lacks photoreceptor cells. At the posterior region of the eye, clusters with variable numbers of photoreceptor cells are seen. The photoreceptor cells degenerate during pupal development.

(Taguchi et al., 2000)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Enhancer of

Statement

Reference

cln[+]/cln^SF3-2 is an enhancer of visible | dominant phenotype of rl^Su23

(Taguchi et al., 2000)

cln[+]/cln^SF3-2 is an enhancer of visible phenotype of Dsor1^Su1, Sos^JC2

(Taguchi et al., 2000)

Suppressor of

Statement

Reference

cln^SF3-2 is a suppressor of visible phenotype of Scer\GAL4^hs.2sev, aos^UAS.cTa

(Taguchi et al., 2000)

cln^SF3-2 is a suppressor of abnormal cell death phenotype of rpr^GMR.PW

(Taguchi et al., 2000)

cln^SF3-2 is a suppressor of visible phenotype of rpr^GMR.PW

(Taguchi et al., 2000)

cln^SF3-2 is a suppressor of visible phenotype of Ras85D^N17.sev

(Taguchi et al., 2000)

cln^SF3-2 is a suppressor of abnormal cell death phenotype of hid^GMR.PG

(Taguchi et al., 2000)

cln^SF3-2 is a suppressor of visible phenotype of aos^hs.PSa

(Taguchi et al., 2000)

Other

Statement

Reference

aos^GMR.PS, cln^SF3-2 has visible phenotype

(Taguchi et al., 2000)

Phenotype Manifest In

Enhancer of

Statement

Reference

cln[+]/cln^SF3-2 is an enhancer of wing phenotype of rl^Su23

(Taguchi et al., 2000)

cln[+]/cln^SF3-2 is an enhancer of wing vein | ectopic phenotype of rl^Su23

(Taguchi et al., 2000)

cln[+]/cln^SF3-2 is an enhancer of wing vein | ectopic phenotype of Dsor1^Su1, Sos^JC2

(Taguchi et al., 2000)

cln[+]/cln^SF3-2 is an enhancer of wing phenotype of Dsor1^Su1, Sos^JC2

(Taguchi et al., 2000)

NOT Enhancer of

Statement

Reference

cln^SF3-2 is a non-enhancer of phenotype of Ras85D^V12.sev

(Taguchi et al., 2000)

Suppressor of

Statement

Reference

cln^SF3-2 is a suppressor of eye phenotype of aos^hs.PSa

(Taguchi et al., 2000)

cln^SF3-2 is a suppressor of wing phenotype of aos^hs.PSa

(Taguchi et al., 2000)

cln^SF3-2 is a suppressor of eye phenotype of rpr^GMR.PW

(Taguchi et al., 2000)

cln^SF3-2 is a suppressor of eye phenotype of Scer\GAL4^hs.2sev, aos^UAS.cTa

(Taguchi et al., 2000)

cln^SF3-2 is a suppressor of ommatidium phenotype of Scer\GAL4^hs.2sev, aos^UAS.cTa

(Taguchi et al., 2000)

cln^SF3-2 is a suppressor of eye phenotype of Ras85D^N17.sev

(Taguchi et al., 2000)

cln^SF3-2 is a suppressor of ommatidium phenotype of Ras85D^N17.sev

(Taguchi et al., 2000)

cln[+]/cln^SF3-2 is a suppressor of phenotype of aos^GMR.PS

(Taguchi et al., 2000)

NOT Suppressor of

Statement

Reference

cln^SF3-2 is a non-suppressor of phenotype of Ras85D^V12.sev

(Taguchi et al., 2000)

Other

Statement

Reference

aos^GMR.PS, cln^SF3-2 has eye phenotype

(Taguchi et al., 2000)

aos^GMR.PS, cln^SF3-2 has ommatidium phenotype

(Taguchi et al., 2000)

Additional Comments

Genetic Interactions

Statement

Reference

Dominantly suppresses the argos^GMR.PS eye phenotype. Has little or no effect on the Ras85D^V12.sev eye phenotype. Suppresses the Ras85D^N17.sev eye phenotype. Suppresses the argos^hs.PSa eye and wing phenotypes. Suppresses the rpr^GMR.PW cell death and small eye phenotypes. Suppresses the W^GMR.PG cell death phenotype. Suppresses the rpr^GMR.PW cell death and small eye phenotypes. Suppresses the rough eye phenotype caused by expression of argos^Scer\UAS.cTa under the control of Scer\GAL4^hs.2sev. Dsor1^Su1/Y ; Sos^JC2/+ flies have extra wing veins. This phenotype is enhanced by one copy of cln^SF3-2. Dominantly enhances the extra wing vein phenotype of rl^Su23/+ flies.

(Taguchi et al., 2000)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

Selected as: a dominant modifier of the rough eye phenotype caused by argos^GMR.PS.

(Taguchi et al., 2000)

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (2)

Reported As

Symbol Synonym

SF3-2

(Taguchi et al., 2000)

cln^SF3-2

Name Synonyms

Secondary FlyBase IDs

References (1)

Report Sections

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