FlyBase Allele Report: Dmel\PolG1[γ125.UAS]

General Information

Symbol

Dmel\PolG1^γ125.UAS

Species

D. melanogaster

Name

FlyBase ID

FBal0119115

Feature type

allele

Associated gene

Dmel\PolG1

Associated Insertion(s)

Carried in Construct

P{UAS-γ125}

Key Links

Transgenic product class

cDNA

(Lefai et al., 2000)

wild_type

(Lefai et al., 2000)

Mutagen

in vitro construct

Nature of the Allele

Transgenic product class

cDNA

(Lefai et al., 2000)

wild_type

(Lefai et al., 2000)

Mutagen

in vitro construct

(Lefai et al., 2000)

Progenitor genotype

Carried in construct

P{UAS-γ125}

Cytology

Description

UAS sequences drive expression of the complete tam cDNA.

(Lefai et al., 2000)

Allele components

Component

Use(s)

Regulatory region(s)

UAS

binary expression system - regulatory region

Encoded product / tool

PolG1

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

Phenotype Manifest In

adult cuticle, with Scer\GAL4^hs.PB

(Lefai et al., 2000)

eye, with Scer\GAL4^hs.PB

(Lefai et al., 2000)

leg, with Scer\GAL4^hs.PB

(Lefai et al., 2000)

macrochaeta, with Scer\GAL4⁴⁴⁴

(Lefai et al., 2000)

macrochaeta, with Scer\GAL4^hs.PB

(Lefai et al., 2000)

mesothoracic tergum, with Scer\GAL4^hs.PB

(Lefai et al., 2000)

pupal cuticle, with Scer\GAL4⁴⁴⁴

(Lefai et al., 2000)

wing, with Scer\GAL4^hs.PB

(Lefai et al., 2000)

wing margin bristle, with Scer\GAL4^hs.PB

(Lefai et al., 2000)

Detailed Description

Statement

Reference

When tam^{γ125.Scer\UAS} is constitutively expressed under the control of Scer\GAL4⁴⁴⁴, some cuticular defects are apparent in the pupa, including the lack of several macrochaetae. When tam^{γ125.Scer\UAS} is expressed under the control of Scer\GAL4^hs.PB and subjected to heatshock pulses, no lethality is observed. However defects in the cuticularized structures of the emerging adults, including the eye, notum, wing and leg, that become more apparent and frequent as the severity of the heat-shock treatment increases. Abnormalities in the number and position of some bristles are apparent in the eye. Several alterations are seen in the notum, including loss of macrochaetae, disruptions in the pattern of the bristles are also frequently detected along the wing margin.

(Lefai et al., 2000)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Phenotype Manifest In

Additional Comments

Genetic Interactions

Statement

Reference

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (3)

Reported As

Symbol Synonym

PolG1^γ125.UAS

tam^{γ125.Scer\UAS}

tam^γ125.UAS

Name Synonyms

Secondary FlyBase IDs

References (1)

Report Sections

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