FlyBase Allele Report: Dmel\l(2)k10113[EP1221]

General Information

Symbol

Dmel\l(2)k10113^EP1221

Species

D. melanogaster

Name

FlyBase ID

FBal0119654

Feature type

allele

Associated gene

l(2)k10113

Associated Insertion(s)

P{EP}l(2)k10113^EP1221

Carried in Construct

Also Known As

EP(2)1221

Key Links

Genomic Maps

JBrowse

Allele class

Mutagen

P-element activity

Nature of the Allele

Allele class

Mutagen

P-element activity

(Pena-Rangel et al., 2002, Gene Disruption Project members, 2001-, Abdelilah-Seyfried et al., 2000)

Progenitor genotype

Associated Insertion(s)

P{EP}l(2)k10113^EP1221

Cytology

Description

Allele components

Component

Use(s)

Inserted element

P{EP}

misexpression element

Regulatory region(s)

UAS

binary expression system - regulatory region

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

transposable_element_insertion_site

2L:7,423,763..7,423,763 [+]

(Maybeck and Röper, 2009, Pena-Rangel et al., 2002, Gene Disruption Project members, 2001-, Abdelilah-Seyfried et al., 2000)

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

visible, with Scer\GAL4^GMR.PF

(Müller et al., 2005)

visible, with Scer\GAL4^sca-537.4

(Abdelilah-Seyfried et al., 2000)

Phenotype Manifest In

dorsocentral bristle, with Scer\GAL4^sca-537.4

(Abdelilah-Seyfried et al., 2000)

embryonic/larval salivary gland, with Scer\GAL4^fkh.PH

(Maybeck and Röper, 2009)

eye, with Scer\GAL4^GMR.PF

(Müller et al., 2005)

scutellar bristle, with Scer\GAL4^sca-537.4

(Abdelilah-Seyfried et al., 2000)

tormogen cell, with Scer\GAL4^sca-537.4

(Abdelilah-Seyfried et al., 2000)

Detailed Description

Statement

Reference

Expression via Scer\GAL4^fkh.PH results in a strongly penetrant gland shape/lumen ('shepherd's crook') phenotype in the embryonic salivary gland.

(Maybeck and Röper, 2009)

Expression of l(2)k10113^EP1221 under the control of Scer\GAL4^GMR.PF results in a big eye phenotype.

(Müller et al., 2005)

Expression of l(2)k10113^EP1221 under the control of Scer\GAL4^sca-537.4 results in loss of scutellar and dorsocentral macrochaetae. Sensory organs with no socket and one shaft are seen.

(Abdelilah-Seyfried et al., 2000)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

NOT Enhanced by

Statement

Reference

Scer\GAL4^sca-537.4, l(2)k10113^EP1221 has visible phenotype, non-enhanceable by H[+]/H^E21

(Abdelilah-Seyfried et al., 2000)

Scer\GAL4^sca-537.4, l(2)k10113^EP1221 has visible phenotype, non-enhanceable by N[+]/N^55e11

(Abdelilah-Seyfried et al., 2000)

NOT suppressed by

Statement

Reference

Scer\GAL4^sca-537.4, l(2)k10113^EP1221 has visible phenotype, non-suppressible by H[+]/H^E21

(Abdelilah-Seyfried et al., 2000)

Scer\GAL4^sca-537.4, l(2)k10113^EP1221 has visible phenotype, non-suppressible by N[+]/N^55e11

(Abdelilah-Seyfried et al., 2000)

Enhancer of

Statement

Reference

l(2)k10113^EP1221/Scer\GAL4^pnr-MD237 is an enhancer of visible phenotype of pnr^MD237

(Pena-Rangel et al., 2002)

Suppressor of

Statement

Reference

l(2)k10113^EP1221, Scer\GAL4^GMR.PF is a suppressor of visible phenotype of H^UAS.cMa, Scer\GAL4^GMR.PF

(Müller et al., 2005)

Phenotype Manifest In

Enhancer of

Statement

Reference

l(2)k10113^EP1221/Scer\GAL4^pnr-MD237 is an enhancer of chaeta phenotype of pnr^MD237

(Pena-Rangel et al., 2002)

NOT Enhancer of

Statement

Reference

l(2)k10113^EP1221/Scer\GAL4^sca-537.4 is a non-enhancer of phenotype of N^55e11

(Abdelilah-Seyfried et al., 2000)

l(2)k10113^EP1221/Scer\GAL4^sca-537.4 is a non-enhancer of phenotype of H^E21

(Abdelilah-Seyfried et al., 2000)

Suppressor of

Statement

Reference

l(2)k10113^EP1221, Scer\GAL4^GMR.PF is a suppressor of eye phenotype of H^UAS.cMa, Scer\GAL4^GMR.PF

(Müller et al., 2005)

NOT Suppressor of

Statement

Reference

l(2)k10113^EP1221/Scer\GAL4^sca-537.4 is a non-suppressor of phenotype of H^E21

(Abdelilah-Seyfried et al., 2000)

Other

Statement

Reference

Scer\GAL4^pnr-MD237, l(2)k10113^EP1221, pnr^MD237/pnr[+] has dorsocentral bristle phenotype

(Pena-Rangel et al., 2002)

Scer\GAL4^pnr-MD237, l(2)k10113^EP1221, pnr^MD237/pnr[+] has microchaeta phenotype

(Pena-Rangel et al., 2002)

Scer\GAL4^pnr-MD237, l(2)k10113^EP1221, pnr^MD237 has dorsocentral bristle phenotype

(Pena-Rangel et al., 2002)

Scer\GAL4^pnr-MD237, l(2)k10113^EP1221, pnr^MD237 has microchaeta phenotype

(Pena-Rangel et al., 2002)

Additional Comments

Genetic Interactions

Statement

Reference

pnr^MD237/+ adults expressing l(2)k10113^EP1221 under the control of Scer\GAL4^pnr-MD237 show loss of dorsocentral macrochaetae and microchaetae without polarity.

(Pena-Rangel et al., 2002)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

Selected as: a P{EP} insertion line that modifies the pnr^MD237/+ phenotype when expressed using Scer\GAL4^pnr-MD237.

(Pena-Rangel et al., 2002)

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (3)

Reported As

Symbol Synonym

EP(2)1221

(Abdelilah-Seyfried et al., 2001, Abdelilah-Seyfried et al., 2000)

EP1221^EP1221

l(2)k10113^EP1221

Name Synonyms

Secondary FlyBase IDs

References (6)

Report Sections

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