FB2024_03 , released June 25, 2024
Allele: Dmel\ptc34
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General Information
Symbol
Dmel\ptc34
Species
D. melanogaster
Name
FlyBase ID
FBal0121593
Feature type
allele
Associated gene
Dmel\ptc
Associated Insertion(s)
Carried in Construct
Key Links
Genomic Maps

Allele class
Mutagen
Nature of the Allele
Allele class
Mutagen
ethyl methanesulfonate
(Strutt et al., 2001)
Progenitor genotype
Cytology
Description

Amino acid replacement: G477R.

(Strutt et al., 2001)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
point_mutation
2R:8,661,588..8,661,588 [+]
Nucleotide change:

G8661588C

Amino acid change:

G477R | ptc-PA

Reported amino acid change:

G477R

Comment:

Site of nucleotide substitution in mutant inferred by FlyBase based on reported amino acid change.

(Strutt et al., 2001)
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      ptc34/ptctuf-1 flies have enlarged eyes and enlarged head vertex (ocellar triangle, fronto-orbital plate and frons). Other head defects in these flies vary from outgrowths of head cuticle plus large numbers of missing, misplaced or ectopic head bristles to one or 2 misplaced or missing head bristles. ptc559.1/ptc34 flies have normal sized eyes and head vertex and a low incidence of ectopic or misplaced head bristles.

      (Thomas and Ingham, 2003)

      Mutants transheterozygous for ptctuf-1 and ptc34 show normal separation of wing veins L3 and L4, but display dramatic shape changes and abnormalities in the anterior margin. The wing becomes almost circular and the triple row bristles are replaced by double row bristles.

      (Strutt et al., 2001)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Suppressor of
      Statement
      Reference

      ptc34/ptctuf-1 is a suppressor of eye phenotype of hhbar3

      (Thomas and Ingham, 2003)
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (1)
      Reported As
      Symbol Synonym
      ptc34
      Name Synonyms
      Secondary FlyBase IDs
        References (3)