FB2024_03 , released June 25, 2024
Allele: Dmel\nompB1
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General Information
Symbol
Dmel\nompB1
Species
D. melanogaster
Name
FlyBase ID
FBal0121649
Feature type
allele
Associated gene
Dmel\nompB
Associated Insertion(s)
Carried in Construct
Key Links
Allele class
Mutagen
    Nature of the Allele
    Allele class
    Mutagen
    Progenitor genotype
    Cytology
    Description

    Contains a 1100bp deletion tha removes exon 4 and part of exon 3. This results in a mis-splicing of exon 2 to exon 5 and a frameshift at amino acid 109 that yields a 110 amino acid truncated protein.

    (Han et al., 2003)
    Mutations Mapped to the Genome
    Curation Data
    Type
    Location
    Additional Notes
    References
    Variant Molecular Consequences
    Associated Sequence Data
    DDBJ / EMBL / GenBank
    DNA sequence
    Protein sequence
     
    UniProtKB/Swiss-Prot
      UniProtKB/TrEMBL
        Expression Data
        Reporter Expression
        Additional Information
        Statement
        Reference
         
        Marker for
        Reflects expression of
        Reporter construct used in assay
        Human Disease Associations
        Disease Ontology (DO) Annotations
        Models Based on Experimental Evidence ( 0 )
        Disease
        Evidence
        References
        Modifiers Based on Experimental Evidence ( 0 )
        Disease
        Interaction
        References
        Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
         
        Disease-implicated variant(s)
         
        Phenotypic Data
        Phenotypic Class
        Phenotype Manifest In
        Detailed Description
        Statement
        Reference

        nompB1/Df(2L)03832MR1 males carrying nompBΔX.Scer\UAS driven by Scer\GAL4elav-C155 are fertile. The offensive competitive ability of sperms from these males is also unaffected; the last-male sperm precedence usually seen is unaffected.

        (Han et al., 2003)

        Flies are uncoordinated showing frequent leg crossing and wings held up or out. Walking and righting ability is impaired. Spontaneous or induced (by light or mechanical stimuli) activity is vigorous. Mechanoreceptor potentials are invariably absent in thoracic macrochaete bristles. The sound evoked response (measured via the antennal nerve) is eliminated. ERGs are normal.

        (Eberl et al., 2000)
        External Data
        Interactions
        Show genetic interaction network for Enhancers & Suppressors
        Phenotypic Class
        Phenotype Manifest In
        Additional Comments
        Genetic Interactions
        Statement
        Reference
        Xenogenetic Interactions
        Statement
        Reference
        Complementation and Rescue Data
        Images (0)
        Mutant
        Wild-type
        Stocks (0)
        Notes on Origin
        Discoverer
        External Crossreferences and Linkouts ( 0 )
        Synonyms and Secondary IDs (1)
        Reported As
        Symbol Synonym
        nompB1
        (Park et al., 2013, Enjolras et al., 2012)
        Name Synonyms
        Secondary FlyBase IDs
          References (4)