FB2024_03 , released June 25, 2024
Allele: Dmel\fs(1)Yb72
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General Information
Symbol
Dmel\fs(1)Yb72
Species
D. melanogaster
Name
FlyBase ID
FBal0121760
Feature type
allele
Associated gene
Dmel\fs(1)Yb
Associated Insertion(s)
Carried in Construct
Also Known As
Yb72
Key Links
Genomic Maps

Allele class
Mutagen
Nature of the Allele
Allele class
Mutagen
ethyl methanesulfonate
(Swan et al., 2001)
Progenitor genotype
Cytology
Description

Amino acid replacement: ?134term.

(King et al., 2001)

Nucleotide substitution: G566A.

(King et al., 2001)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
point_mutation
X:2,721,030..2,721,030 [+]
Nucleotide change:

G2721030A

Reported nucleotide change:

G566A

Amino acid change:

W135term | fs(1)Yb-PA

Reported amino acid change:

?134term

Comment:

TGG to TAG

(King et al., 2001)
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Homozygous males have morphologically normal testes and are fully fertile.

      (Szakmary et al., 2009)

      The number of Sxl-expressing cells at the anterior tip of the germarium is increased in homozygous females, and they often take up the entire anterior half of the germarium. The number of spectrosome containing cells is greater than normal and increases with the age of the female. Very few 16-cell cysts are formed and germaria become cleared of dividing cystocyte clusters within 24 hours. Germline clones produce wild-type eggs, indicating a somatic requirement for fs(1)Yb.

      (Swan et al., 2001)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Other
      Statement
      Reference

      G38G38, fs(1)Yb72 has male sterile | recessive phenotype

      (Szakmary et al., 2009)
      Phenotype Manifest In
      Suppressed by
      Statement
      Reference

      fs(1)Yb72 has phenotype, suppressible by hhhs.PI

      (King et al., 2001)
      Other
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      The testes of fs(1)Yb72 ; G38G38 double homozygous males lose their germline shortly after eclosion and are almost completely sterile.

      (Szakmary et al., 2009)

      fs(1)Yb72 ; bamΔ86 double mutant ovaries display the same phenotype as seen in bamΔ86 single mutants.

      (Szakmary et al., 2005)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Images (0)
      Mutant
      Wild-type
      Stocks (1)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (3)
      References (9)