FlyBase Allele Report: Dmel\drm[3]

General Information

Symbol

Dmel\drm³

Species

D. melanogaster

Name

FlyBase ID

FBal0121796

Feature type

allele

Associated gene

Dmel\drm

Associated Insertion(s)

roo{}drm³

Carried in Construct

Key Links

Genomic Maps

JBrowse

Allele class

Mutagen

spontaneous

Nature of the Allele

Allele class

Mutagen

spontaneous

(Green et al., 2002)

Progenitor genotype

Associated Insertion(s)

roo{}drm³

Cytology

Description

roo element insertion at the exon 2 splice donor site.

(Green et al., 2002)

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

transposable_element_insertion_site

2L:3,545,808..3,545,809 [+]

(Green et al., 2002)

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

lethal (with Df(2L)drm-P2)

(Kahsai et al., 2016)

Phenotype Manifest In

embryonic hindgut

(Green et al., 2002)

embryonic hindgut (with drm⁶)

(Johansen et al., 2003)

embryonic proventriculus

(Green et al., 2002)

Detailed Description

Statement

Reference

Mutant clones in the leg do not have a detectable effect on leg segmentation or growth.

(Hao et al., 2003)

drm³/drm⁶ embryos have short and wide hindguts with an excessive number of cells in their circumference.

(Johansen et al., 2003)

Mutant embryos have hindgut defects. The proventriculus is both morphologically and functionally defective.

(Green et al., 2002)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Phenotype Manifest In

Suppressed by

Statement

Reference

drm⁶/drm³ has embryonic hindgut phenotype, suppressible by Scer\GAL4^drm.7.1/upd1^UAS.cZa

(Johansen et al., 2003)

NOT Enhancer of

Statement

Reference

drm³ is a non-enhancer of embryonic foregut phenotype of bowl¹, lin^unspecified

(Johansen et al., 2003)

drm³ is a non-enhancer of keyhole structure phenotype of bowl¹, lin^unspecified

(Johansen et al., 2003)

NOT Suppressor of

Statement

Reference

drm³ is a non-suppressor of embryonic foregut phenotype of bowl¹, lin^unspecified

(Johansen et al., 2003)

drm³ is a non-suppressor of keyhole structure phenotype of bowl¹, lin^unspecified

(Johansen et al., 2003)

Additional Comments

Genetic Interactions

Statement

Reference

drm³ bowl¹ double mutant clones in the leg (induced using the Minute technique) have a leg segment fusion phenotype that can be attributed to the loss of bowl alone.

(Hao et al., 2003)

Expression of upd1^Scer\UAS.cZa under the control of Scer\GAL4^drm.7.1 significantly rescues the drm³/drm⁶ mutant hindgut phenotype; the hindgut is more elongated and has fewer cells in its circumference than in drm³/drm⁶ embryos.

(Johansen et al., 2003)

The gut morphology of drm³, bowl¹ double homozygous embryos is indistinguishable from that of single mutants.

(Johansen et al., 2003)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (2)