FlyBase Allele Report: Dmel\Slbp[15]

General Information

Symbol

Dmel\Slbp¹⁵

Species

D. melanogaster

Name

FlyBase ID

FBal0121943

Feature type

allele

Associated gene

Dmel\Slbp

Associated Insertion(s)

P{EP-Δ15}Slbp¹⁵

Carried in Construct

Key Links

Allele class

loss of function allele

Mutagen

P-element activity

Nature of the Allele

Allele class

loss of function allele

(Lanzotti et al., 2004)

Mutagen

P-element activity

(Sullivan et al., 2001)

Progenitor genotype

Slbp^EP3182

(Sullivan et al., 2001)

Associated Insertion(s)

P{EP-Δ15}Slbp¹⁵

Cytology

Description

The P{EP} element has an internal deletion from bps 18-5020.

(Sullivan et al., 2001)

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

lethal

(Sullivan et al., 2001)

lethal - all die before end of pupal stage

(Godfrey et al., 2006)

partially lethal - majority die (with Slbp¹⁰)

(Sullivan et al., 2001)

some die during pupal stage

(Godfrey et al., 2006)

Phenotype Manifest In

Detailed Description

Statement

Reference

Homozygous late stage 16 embryos do not display any defects in the somatic musculature.

(Bulchand et al., 2010)

The hemizygous lethal phase is late in development, with many flies dying at eclosion. About half of Slbp¹⁰/Slbp¹⁵ animals survive to adulthood.

(Sullivan et al., 2001)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Phenotype Manifest In

Other

Statement

Reference

Slbp¹⁵, mute¹²⁸¹/mute[+] has embryonic/larval somatic muscle cell phenotype

(Bulchand et al., 2010)

Additional Comments

Genetic Interactions

Statement

Reference

More than half of mute¹²⁸¹/+ ; Slbp¹⁵/Slbp¹⁵ stage 16 embryos have somatic muscles that appear significantly thinner than normal. Some muscles are detached while others appear to be missing.

(Bulchand et al., 2010)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Fails to complement

Slbp¹²

(Sullivan et al., 2001)

Slbp¹⁹

(Sullivan et al., 2001)

Rescued by

Slbp¹⁵/Df(3R)3450 is rescued by Slbp^+tSa

(Sullivan et al., 2001)

Partially rescued by

Slbp¹⁵/Df(3R)3450 is partially rescued by Slbp^{T120A.T230A.Tag:HA}

(Lanzotti et al., 2004)

Slbp¹⁵/Df(3R)3450 is partially rescued by Slbp^WT.Tag:HA

(Lanzotti et al., 2004)

Slbp¹⁵/Df(3R)3450 is partially rescued by Slbp^T120A.Tag:HA

(Lanzotti et al., 2004)

Slbp¹⁵/Df(3R)3450 is partially rescued by Slbp^T230A.Tag:HA

(Lanzotti et al., 2004)

Comments

Slbp¹⁵/Df(3R)3450 females rescued by one copy of Slbp^{WT.T:Ivir\HA1} are either fertile, moderately fertile, or sterile, depending on the insertion site of Slbp^{WT.T:Ivir\HA1}. All rescued males are fertile. Females rescued by two copies of Slbp^{WT.T:Ivir\HA1} are fully fertile. Flies rescued by one copy of Slbp^{WT.T:Ivir\HA1} are sometimes late-eclosing, depending on the particular insertion. Two copies of the Slbp^{T120A.T:Ivir\HA1} transgene fully rescues the viability and fecundity of Slbp¹⁵/Df(3R)3450 flies. The viability of Slbp¹⁵/Df(3R)3450 mutants with one copy of Slbp^{T120A.T:Ivir\HA1} is usually rescued, depending on insertion of the transgene. Females rescued with one copy of Slbp^{T120A.T:Ivir\HA1} can be sterile or fertile, depending on the insertion, while males are always fertile. Two copies of either the Slbp^{T230A.T:Ivir\HA1} or the Slbp^{T120A.T230A.T:Ivir\HA1} transgene partially rescue the viability of Slbp¹⁵/Df(3R)3450 mutants, but any rescued females are sterile. One copy of Slbp^{T230A.T:Ivir\HA1} or Slbp^{T120A.T230A.T:Ivir\HA1} is not usually sufficient to achieve rescue; any escapers eclose later then wild type and usually die shortly after eclosion. All rescued males are fertile.

(Lanzotti et al., 2004)

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

Comments

An allelic series can be defined for Slbp alleles with respect to viability: Slbp¹⁰ > Slbp¹⁹ > Slbp¹⁵ >= Slbp¹² = Df(3R)3450.

(Sullivan et al., 2001)

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (2)

Reported As

Symbol Synonym

Slbp¹⁵

(Bulchand et al., 2010, Wagner et al., 2007, White et al., 2007, Godfrey et al., 2006)

slbp¹⁵

(Terzo et al., 2015)

Name Synonyms

Secondary FlyBase IDs

References (8)

Report Sections

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