FlyBase Allele Report: Dmel\InR[304]

FB2024_03 , released June 25, 2024

FB2024_03 , released June 25, 2024

Allele: Dmel\InR³⁰⁴

General Information

Symbol

Dmel\InR³⁰⁴

Species

D. melanogaster

Name

FlyBase ID

FBal0122081

Feature type

allele

Associated gene

Associated Insertion(s)

Carried in Construct

Key Links

Genomic Maps

Allele class

Mutagen

Nature of the Allele

Allele class

Mutagen

Progenitor genotype

Cytology

Description

Amino acid replacement: W1439term.

(Brogiolo et al., 2001)

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

3R:21,575,065..21,575,065 [-]

Nucleotide change:

G21575065A

Amino acid change:

W1587term | InR-PA; W1587term | InR-PB; W1587term | InR-PC; W1587term | InR-PD

Reported amino acid change:

W1439term

Comment:

Mutation is in the cytoplasmic region

Comment:

G to A nucleotide change at the second or third position of the wild type Trp codon leads to a nonsense mutation. InR[31] and InR[304] have mutations at adjacent G residues; specific changes for each not reported. The mutation was annotated at the third base of the codon.

(Brogiolo et al., 2001)

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

lethal - all die before end of larval stage (with InR^93Dj-4)

(Oldham et al., 2002)

lethal - all die before end of larval stage (with InR³²⁷)

(Oldham et al., 2002)

some die during larval stage (with InR^93Dj-4)

(Oldham et al., 2002)

some die during larval stage (with InR³²⁷)

(Oldham et al., 2002)

visible | somatic clone

(Junger et al., 2003)

Phenotype Manifest In

adult head capsule | somatic clone

(Junger et al., 2003)

eye disc | somatic clone

(Bateman and McNeill, 2004)

Detailed Description

Statement

Reference

Homozygous clones in the eye disc (induced using the Minute technique) show a strong delay in differentiation of pros-expressing cells.

(Bateman and McNeill, 2004)

Head capsule reduced - pinhead phenotype.

(Junger et al., 2003)

Homozygous mutant clones in the eye disc are smaller than their wild-type sister clones.

(Brogiolo et al., 2001)

External Data

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Suppressed by

Statement

Reference

InR³⁰⁴ has visible | somatic clone phenotype, suppressible | partially by foxo²⁵

(Junger et al., 2003)

InR^93Dj-4/InR³⁰⁴ has lethal | larval stage phenotype, suppressible | partially by Pten^2L100/Pten¹¹⁷

(Oldham et al., 2002)

InR³²⁷/InR³⁰⁴ has lethal | larval stage phenotype, suppressible | partially by Pten^2L100/Pten¹¹⁷

(Oldham et al., 2002)

Suppressor of

Statement

Reference

InR³⁰⁴ is a suppressor of increased cell number phenotype of Ilp2^UAS.cBa, Scer\GAL4^hs.PB

(Brogiolo et al., 2001)

InR³⁰⁴ is a suppressor of increased cell size phenotype of Ilp2^UAS.cBa, Scer\GAL4^hs.PB

(Brogiolo et al., 2001)

InR³⁰⁴ is a suppressor of increased body size phenotype of Ilp2^UAS.cBa, Scer\GAL4^hs.PB

(Brogiolo et al., 2001)

InR³⁰⁴ is a suppressor of visible phenotype of Ilp2^UAS.cBa, Scer\GAL4^hs.PB

(Brogiolo et al., 2001)

Other

Statement

Reference

InR³²⁷/InR³⁰⁴, Pten^2L100/Pten¹¹⁷ has lethal | pupal stage phenotype

(Oldham et al., 2002)

InR^93Dj-4/InR³⁰⁴, Pten^2L100/Pten¹¹⁷ has lethal | pupal stage phenotype

(Oldham et al., 2002)

Phenotype Manifest In

Suppressed by

Statement

Reference

InR³⁰⁴ has adult head capsule | somatic clone phenotype, suppressible | partially by foxo²⁵

(Junger et al., 2003)

Additional Comments

Genetic Interactions

Statement

Reference

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (3)

Reported As

Symbol Synonym

DInr³⁰⁴

(Junger et al., 2003)

InR³⁰⁴

(Funakoshi et al., 2018)

Inr³⁰⁴

(Clancy et al., 2001)

Name Synonyms

Secondary FlyBase IDs

References (6)

Report Sections