FB2024_03 , released June 25, 2024
Allele: Dmel\kayS135103
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General Information
Symbol
Dmel\kayS135103
Species
D. melanogaster
Name
FlyBase ID
FBal0125002
Feature type
allele
Associated gene
Dmel\kay
Associated Insertion(s)
P{lacW}kayS135103
Carried in Construct
Also Known As
kay1351.3
Key Links
Allele class

hypomorphic allele - genetic evidence

Mutagen
Nature of the Allele
Allele class

hypomorphic allele - genetic evidence

(Dequier et al., 2001)
Mutagen
P-element activity
(Dequier et al., 2001)
Progenitor genotype
Associated Insertion(s)
P{lacW}kayS135103
Cytology
Description

Insertion in the large intron immediately downstream of the first exon of kay-γ.

(Hudson and Goldstein, 2008)

P{lacW} insertion in the 17kb intron following the first coding exon.

(Dequier et al., 2001)
Allele components
Component
Use(s)
Inserted element
P{lacW}
Encoded product / tool
lacZ
Tagged with
Tag:NLS(P)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Eggs derived from mosaic egg chambers in which the follicular epithelium is composed of homozygous kayS135103 cells consistently show two phenotypes; the eggs and their respiratory appendages are shorter than normal. In addition, two appendages of different lengths or "paddleless" appendages are often seen. Eggs which appear deflated are laid at a low frequency. The disappearance of nurse cell nuclei that normally occurs in stage 14 egg chambers is delayed in egg chambers in which the follicular epithelium is composed of homozygous kayS135103 cells, with many of the early stage 14 egg chambers containing as many as 15 remaining nurse cell nuclei.

      (Dequier et al., 2001)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      Mosaic egg chambers in which the follicle cells are homozygous for kayS135103 in a bsk1/+ background degenerate during stage 9 and show a complete failure of posteriorwards migration of the main body follicle cells (migration of the border cells appears unaffected).

      (Dequier et al., 2001)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Complements

      kay1

      (Hudson and Goldstein, 2003)
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer

      Due to the location of the P{lacW}kayS135103 insertion it is possible that this insertion may affect kay or fig or both.

      (Hudson and Goldstein, 2008)
      Comments
      Comments

      The P{lacW}kayS135103 insertion maps within the 17.6 intron of kay 2.3kb 5' of fig.

      (Hudson and Goldstein, 2003)

      Precise excision of the insertion reverts the lethal phenotype.

      (Hudson and Goldstein, 2008)
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      kay1351.3
      (Hudson and Goldstein, 2008, Hudson and Goldstein, 2004, Hudson and Goldstein, 2003, Dequier et al., 2001)
      kayS135103
      Name Synonyms
      Secondary FlyBase IDs
        References (4)